The Effect Of α-lipoic Acid On The Heart Function And Other Related Biochemical Indexes Of Diabetic Cardiomyopathy Patients

Objesctive: This study aims to investigate the effect of α-lipoic acid on heart function and other related biochemical indexes. Methods: We randomly divided 80 patients with diabetic cardiomyopathy into two groups: ALA group(n=40) and control group(n=40). Patients in both groups receive standard anti-DCM therapy. While the ALA group received an extra α-lipoic acid therapy. All patients were treated for one month. The level of blood lipid, hsCRP, NT-proBNP, E/A, LVEF and LiHFE scores of both groups were analyzed in appropriate statistical methods. Then compared the efficacy of this two therapy methods. Results:(1)Compared with pre-treatment, the level of TC, LDL-C, hsCRP, NT-proBNP and Li HFE score is lower(P<0.05). These indexes reduced more in ALA group(P<0.05).(2)Compared with pre-treatment, the TG level reduced in ALA group. The difference is statistically significant(P<0.05). The TG level of control group after therapy is not reduced than pre-treatment.The difference is not statistically significant(P>0.05).(3)The level of E/A and LVEF of both groups have raised after therapy(P<0.05). These indexes raised more in ALA group than control group(P<0.05).(4)There is no significant differences of HDL-C level between two groups before and after therapy(P>0.05). Conclusion:(1) α-lipoic acid has a positive effects on reducing TC, TG, LDL-C level of DCM patients. While the effects on raising HDL-C level is unconspicuous.(2) α-lipoic acid can improve heart funcion and improve the life quality of DCM patients.(3) Using α-lipoic acid additionally on the basis of standard therapy can reach a better efficacy for DCM patients.