The Relationship Between The KCNJ5 Gene Polymorphisms And Dyslipidemia In Patients With Primary Aldosteronism

Background: Dyslipidemia is an independent modifiable risk factor for Cardiovascular and Cerebral vascular Disease; Patients with primary aldosteronism are at high risk of lipid metabolism disorders. While the recent study has found that the KCNJ5 gene mutation is not only related to the occurrence of primary aldosterone, but also has a certain correlation with metabolic syndrome. Aim of our study was to assess whether KCNJ5 gene polymorphisms are associated with dyslipidemia among patients with PA.Methods: A total of 494 subjects who diagnosed with primary aldosteronism were recruited.All subjects were divided into two groups according to the blood lipid level:dyslipidemia group(n=338) and non-dyslipidemia group(n=156). The polymorphisms of rs3740835 of KCNJ5 gene were genotyped by Taqman polymerase chain reaction(PCR)in all participants. Results: The distribution of the SNP(rs3740835) genotype and dominant model(CC vs AA + AC) showed significant difference between dyslipidemia group and non-dyslipidemia group(P= 0.001 and P=0.007). Conclusions: Our study demonstrated the polymorphisms of the KCNJ5 gene(rs3740835) may play a role in the development of dyslipidemia in patients with PA.