Luminal Retrospective Analysis Of Diagnosis And Treatment Of Breast Cancer

Objective:to evaluate different type Luminal the clinical pathological characteristics and prognosis of breast cancer molecular subtypes.Methods:a retrospective analysis between December 2012 and June 2012, our hospital surgical treatment of clinical pathology, diagnosis and treatment of tumor biology and breast cancer. According to St Gallen discovered expert consensus (2011) divide the molecular classification of breast cancer. Compare the Luminal A and B type (B1 and B2) clinical pathological characteristics of breast cancer, surgical treatment method, adjuvant chemotherapy scheme, follow-up of postoperative recurrence and metastasis, single factor analysis of different molecular subtypes Luminal differences between clinical pathology and prognosis of breast cancer,< 0.05 there are significant differences in standards, use SPSS21.0 package of data for statistical analysis.Results:the total data of 515 cases of patients with complete, Luminal A type 84 cases (16.3%), Luminal B 265 (51.4%), its ehrs-2 expression type 90 cases (17.6%), three Yin type 76 cases of breast cancer (14.7%).349 cases of breast cancer with Luminal type, Luminal 84 cases of type A, Luminal B1 type 209 cases,56 cases of Luminal B2 type. Except the tumor histological grading (grade 1,2,3) there are significant differences (P< 0.001), the Luminal A, B1 and Luminal Luminal B2 three groups of breast cancer in the onset age, menopausal status (cT), tumor size, lymph node metastasis (pN), clinical stage, tumor histological classification and grading, vascular tumor emboli, and surgical procedure, postoperative radiotherapy, chemotherapy and endocrine treatment had no significant difference. Postoperative follow-up of 8-38 months, an average of 23 months. Follow-up rate was 92.5%, postoperative ipsilateral Luminal type A chest wall recurrence in 4 cases, the contralateral breast recurrence in 1 case, postoperative have internal transfer in 1 case (lungs, liver, bone 100).12,24,38 monthsostoperative recurrence metastasis 0 cases,3 cases,6 cases. Luminal B1 type (HER2) 10 cases of postoperative recurrence of chest wall on the same side,4 cases of recurrence, the contralateral breast surgery have internal transfer 4 cases (lungs, liver, bone 21).12,24,38 months after the transfer of recurrence in 2 cases,15 cases,18 cases. LuminalB2 (HER2 +) type 4 cases of postoperative ipsilateral chest wall recurrence,0 cases, the contralateral breast recurrence after surgery has spread to the viscera in 1 case (lungs, liver, bone 100),12,24,38 months after the transfer of recurrence in 1 case,4 cases of how many cases,5 cases of recurrence of each transferConclusion:1, Luminal breast cancer was highest among various types of breast cancer, and given priority to with infiltrating ductalcarcinoma.2, Luminal breast cancer prognosis is type B well, there are differences between the histological grading of the two type 3, different molecular subtypes Luminal breast cancer postoperative DFS is no statistical difference, but the results show that the time is LuminalA LuminalB type of breast cancer recurrence type has A tendency to earlier.4, to the ER, PR, Ki67 and its ehrs-2 immunohistochemical expression based on molecular classification of breast cancer postoperative alternative treatments have practical guiding value, but still need to improve.