| Background: The correlation between serum levels of soluble ST2(sST2) with chronic heart failure and its mechanism has not beenfully understood.Researches about sST2 relevant factors, such as age, sex, ethnicity, BNP, LVEF values, LVEDD value, serum Creatinine, cystatin C, weight and other relevant factors less. Objective: To observe changes of solubleST2 in patients with chronic heart failure and observe the relationship between sST2 with age, sex, ethnicity, BNP, LVEF values, LVEDD value, serum Creatinine, cystatin C, weight and other factors. Methods:(1) Enrolled 209 patients who were admitted into the First Affiliated Hospital of Xin Jiang Medical University from January 2015 to June 2016,from which selected group of 101 cases of heart failure, according to the NYHA 38 of which belongs to classⅡ, 53 belongs to class III,10 belongs to class Ⅳ; 108 casesin the control group. Observe the changes in serum concentrations of soluble ST2 between the two groups.(2)The heart failure patients were divided into two groups of ethnic Han and Uygur, then compare the differences in Serum Soluble ST2 between two groups.(3)Study the line arregression analysis between soluble ST2 with factors such as age, sex, ethnicity, BNP, LVEF values, LVEDD value, serum Creatinine, cystatin C, weight others. Results:(1)Serum concentrations of soluble ST2 value between the heart failure group and the control group was statistically Significant(P<0.05),serum soluble ST2 in NYHA function all class Ⅱ, classⅢand class Ⅳof the difference between each others were statistically significant(P<0.05).(2) Conducted between the two ethnic Han and Uygur serum concentrations of soluble ST2 no statistical significance.(3) Linearregression analysis showed that BNP, LVEF value, serum creatinine, cystatin Cand serumsolublesST2significantlycorrelated(P<0.05);Age, sex, ethnicity, LVEDD value, body weight, gender and serum solubles ST2 is irrelevantor no significant relationship, which was not statistically significant. Conclusion: Patients with chronic heart failure has a significantly higher soluble ST2, and with the increasing of heart function level the sST2 levels were significantly higher, and the BNP, serum creatinine values and cystatin C were increased, LVEF value was decreased. |
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