Correlation Of Clinical Analysis Of Patients With Moderate And Severe Traumatic Brain Injury To Serum Protein Levels And Prognosis

Objective: To retrospective analysis the relationship between serum protein level changes and prognosis of patients after moderately and severe brain injury.Methods: Choice 100 patients with craniocerebral injury treated in our study in February 2014 to September 2015. Glasgow coma scale(GCS) are under 12 points. On the first day, the third day,the fifth day, the seventh day,the ninth day,the eleventh day each patients in hospital phlebotomize detection of serum albumin, interleukin-6, hypersensitive c-reactive protein level on an empty stomach And by calculating the average hospital stay.All cases according to GCS score divide into two groups of moderate and severe. According to the death or not are divided into two groups of death and survival. Survival patients according to the evaluation of active ability of daily life(ADL) score when out of the hospital was divided into good prognosis and prognosis of defect group. Every three kinds of protein levels were compared between the two groups of the above. Respectively analyzed the correlation between ADL scores of survival patients and three kinds of protein levels change.Results:(1) Each group Serum albumin comparison: the first day in hospital serum albumin levels difference of every patients have no obvious statistical significance(P<0.05).During the period of hospital Average albumin severe relative moderate group decreased obviously; Death group relative survival group decreased obviously; The group of defective prognosis relative good prognosis group decreased obviously. The difference was statistically significant(P<0.05). There is a positive correlation between albumin levels on average of survival patients and ADL scores(r=0.483,P<0.05).(2) Each group interleukin- 6 comparison: The level of the first day in hospital and average level of IL-6　severe group obviously higher in the moderate group; Death group relative survival group elevated obviously; The group of defective prognosis relative good prognosis group elevated obviously, the difference was statistically significant(P<0.05).;There is a negative correlation between interleukin-6 levels on average of survival patients and ADL scores(r=-0.815,P<0.05).(3) Each group hypersensitive c-reactive protein level comparison: The level of the first day in hospital and average level of c-reactive protein severe group obviously higher in the moderate group; Death group relative survival group elevated obviously; The group of defective prognosis relative good prognosis group elevated obviously, the difference was statistically significant(P<0.05).;There is a negative correlation between c-reactive protein levels on average of survival patients and ADL scores(r=-0.801,P<0.05).Conclusion: There is a close relationship between serum albumin, IL-6, c-reactive protein level change and the prognosis of patients of moderately and severe craniocerebral injury patients. Serum protein level change can provide powerful basis for judging the prognosis of patients with craniocerebral injury patients.