| Objective:Liver cirrhosis is a common chronic liver disease in clinic.Liver cirrhosis can develop into hepatocellular carcinoma or cause severe complications and death. The aim of this study is to investigate the relationship between indirect bilirubin, haptoglobin and the degree of liver fibrosis. So it can provide a reference for the assessment of liver fibrosis degree and the diagnosis of early liver cirrhosis in patients with liver diseases. Methods:We selected the patients which are admitted to outpatient department of liver and gallbladder pancreas department of the first hospital of Jilin University between July 1, 2015 to December 31, 2015. These 76 patients had previously been diagnosed as liver disease(chronic hepatitis B and chronic hepatitis C, non-alcoholic fatty liver disease). Meanwhile, these patients also need to meet the following conditions:elevated indirect bilirubin,normal direct bilirubin, elevated or normal total bilirubin.According to the disease type, these patients are divided into 2 groups, Specific groups are as follows: 1. There are 56 cases in chronic viral hepatitis group, including 52 cases of chronic hepatitis B, 4 cases of chronic hepatitis C, at the same period, we respectively selected the patients which are admitted to outpatient department of the first hospital of Jilin University, these patients both have normal indirect bilirubin,normal direct bilirubin, normal total bilirubin,including 104 cases of chronic hepatitis B, 8 cases of chronic hepatitis C and 112 cases which have normal indirect bilirubin, normal direct bilirubin, normal total bilirubin are come from the Center of Health Examintion, Which are 1: 2 matched, according to the age and gender.2. There are 20 cases in non-alcoholic fatty liver disease group, at the same period, we selected respectively the patients which are admitted to outpatient department of the first hospital of Jilin University, these patients both have normal indirect bilirubin, normal direct bilirubin, normal total bilirubin, including 40 cases and 40 cases which have normal indirect bilirubin, normal direct bilirubin, normal total bilirubin are come from the Center of Health Examintion, Which are 1: 2 matched, according to the age and gender. Prospective analysis method was selected and the data were statistically analyzed. We explored the significance of indirect bilirubin and haptoglobin in chronic viral hepatitis and non-alcoholic fatty liver disease. At the same time, we analyzed the correlation between indirect bilirubin, total bilirubin, direct bilirubin, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, alkaline phosphatase, cholinesterase, albumin, total bile acids, haptoglobin, platelet, liver stiffness, fatty attenuation and spleen thickness of spleen. Results:1.Comparison between the chronic viral hepatitis patients with elevated IBIL group and health examination people with normal IBIL:In those patients which with chronic viral hepatitis which with elevated IBIL, the level of ALT, AST, ALB and haptoglobin has significantly difference between the health examination people with normal IBIL, P<0.05;2.Comparison between the chronic viral hepatitis patients with elevated IBIL group and chronic viral hepatitis patients with IBIL normal group:In those patients which with chronic viral hepatitis which with elevated IBIL, the level of thickness of spleen, liver stiffness, fatty attenuation,haptoglobin has significantly difference between the chronic viral hepatitis patients with normal IBIL, P<0.05;3.Comparison between the non-alcoholic fatty liver disease patients with elevated IBIL group and health examination people with normal IBIL:In those patients which with non-alcoholic fatty liver disease patients which with elevated IBIL, the level of ALT, AST has significantly difference between the health examination people with normal IBIL, P<0.05;4.Comparison between the non-alcoholic fatty liver disease patients with elevated IBIL group and non-alcoholic fatty liver disease patients with IBIL normal group:In those patients which with non-alcoholic fatty liver disease which with elevated IBIL, the level of fatty attenuation has significantly difference between the non-alcoholic fatty liver disease patients with normal IBIL, P<0.05;5.The relevant comparison between IBIL and other indicators in the group of chronic viral hepatitis patients with elevated IBIL:The indirect bilirubin level is positively correlated with the level of total bilirubin, direct bilirubin,fatty attenuation, liver stiffness, thickness of spleen. The level of indirect bilirubin is negatively correlated with the level of platelet and haptoglobin;6.The relevant comparison between IBIL and other indicators in the group of the non-alcoholic fatty liver disease patients with elevated IBIL:The indirect bilirubin level is positively correlated with the level of total bilirubin;7.The relevant comparison between haptoglobin and other indicators in the group of chronic viral hepatitis patients with elevated IBIL:The haptoglobin level is positively correlated with the level of platelet, The haptoglobin level is negatively correlated with the level of total bilirubin, direct bilirubin, indirect bilirubin, thickness of spleen and liver stiffness;8.The relevant comparison between haptoglobin and other indicators in the group of the non-alcoholic fatty liver disease patients with elevated IBIL:The haptoglobin level is positively correlated with the level of ALP. Conclusions:1.Viral hepatitis with merely indirect bilirubin the degree of liver fibrosis is higher than the patients with normal indirect bilirubin, there may be early liver cirrhosis.2.Non-alcoholic fatty liver disease patients with merely indirect bilirubin increased, the increased indirect bilirubin has little relationship with hemolysis, may be has relationship with fatty acid which can restrain uridine diphosphophoglucuronate glucuronosyl transferase, sequentially the indirect bilirubin increased. |
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