The Pharmaceutical Research Of Compound Huang Chen Capsules

With dry stool,prolonged defecation and difficult defecation,as the main symptoms of chronic constipation disease,the incidence of this disease is increasing year by year.It is very important to further research on the cure of the diseasea nd product a stable and competitive products with the modernization of traditional Chinese medicine.Compound Huang Chen capsule is a kind of compound preparation of traditional Chinese medicine that can relieve constipation, mainly composed of Prepared Radix et Rhizoma Rhei, Pericarpium Citri Reticulatae, bitter almond. The prescription can play the role of pemoving body heat,ceaning the bowels,removing blood stasis,dredging meridians,regulating qi,strengthening spleen,nourishing the heart,calming the mind.The prescription can not only treat constipation but also regulate the gastrointestinal function of patients,improve the patient’s physical fitness, and ultimately improve the quality of life of patients.In the compound Huang Chen capsule,Prepared Radix et Rhizoma Rhei is a monarch drug,so the evaluation index is aloe emodin, rhein, emodin,chrysophanol, physcione. In this prescription, the anthraquinones of the Prepared Radix et Rhizoma Rhei mainly dissolved in water, ethanol and other organic reagents is the main component to play a laxative effect.Considering the solubility of the flavonoid of Pericarpium Citri Reticulatae,fatty oil of bitter almond, the economic, convenience and so on in the process of experiment,using ethanol refluxing method extract medical material.By using orthogonal test, The best extraction process is optimized.The study of preparation technology of dosage forms was carried out in this paper.Choose suitable adhesives and fillers,determined the proportion of main drug and excipients,determined the optimal molding process:Crushed Prepared rheum officinale bail,Pericarpium Citri Reticulatae,bitter almond, extraced with 70%ethanol,filtered and concentrated the extract,added starch etc,preparated granule with 75% ethanol,dried grains in40℃,arrangemented grains, made capsules and packaged and finished.Establish the quality standard of compound Huang Chen capsule:identificated Prepared Radix et Rhizoma Rhei,Pericarpium Citri Reticulatae by TLC, according to the requirement of “Chinese Pharmacopoeia 2015 edition” in the general principles of the four preparation sexaminated the corresponding item, determinated the content of the capsule,researched the methodology.The results showed that,comparing with the contrast medicinal herbs and control article,the test showed the same spots in the same position on the TLC,and the negative samples had no corresponding spots at the corresponding position.Under the capsule item, weight difference, disintegration time limit and microbial limit test were all in accordance with the regulations.aloe.emodin, rhein, emodin, chrysophanol, physcione both showed good linear relationship.Experiment show that the method had good reproducibility,highly specificireliable,high accurac and can be better control the quality of the product.Carry out stability test,Study on the character,inspection, identification, content index of compound Huang Chen capsule in the Room temperature test, accelerated test, the result shows that the stability of the compound Huang Chen capsule is good.