Study On The Relationship Between TCM Syndrome Type And Neural Electrophysiology In Chronic Renal Failure Peripheral Neuropathy

Objective:To explore the relationship between syndrome which based on the theory of traditional Chinese medicine (TCM) and electromyography examination in chronic renal failure peripheral neuropathy by analzing the differences among the neurophysiological parameters of different types of TCM syndrome, and to provide valuable objective quantitative index for the TCM syndrome differentiation.Methods:According to the diagnostic criteria of chronic renal failure and chronic renal failure peripheral neuropathy to determine the selected object; based on TCM diagnostic criteria, the selected object types were divided into:Spleen and kidney Qi syndrome,dampness type, blood stasis type, Spleen and kidney Yang-deficiency type. All patients were treated with EMG nerve electrophysiological examination were detected median nerve, ulnar nerve, tibial nerve, peroneal nerve motor nerve conduction velocity (MCV), compound muscle action potential (CMAP) amplitude, Sensory nerve conduction velocity of the median nerve, ulnar nerve, superficial peroneal nerve (SCV), sensory nerve action potentials (SNAP) amplitude, and the tibial nerve minimum F wave latency (Fdlat), F wave velocity (Fcv); Record all the patients’ age, disease duration, serum creatinine (Scr), blood urea nitrogen (Bun), Parathyroid hormone (PTH) and so on. Analysis of Variance was used in processing data and explored the relationship between each TCM syndrome and electromyography examination, patients’ age, disease duration, Scr, Bun, PTH.Results:There were significant differences in duration compared each syndrome type (P<0.05), the longest duration is Spleen and kidney Yang-deficiency, Spleen and kidney Yang-deficiency type> blood stasis> damPness type> Spleen and kidney Qi syndrome; compared with various syndromes, serum creatinine, blood urea nitrogen, Parathyroid hormone were higher than normal, the highest is Spleen and kidney Yang-deficiency type; the comparison of MCV-. SCV invarious syndromes, Spleen and kidney Yang-deficiency significant difference compared with the dampness type, blood stasis, Spleen and kidney Qi syndrome (P<0.05), the tibial nerve and superficial Peroneal nerve represent the most obvious difference in lower extremity nerve; Comparing CMAP and SNAP amplitude in different groups, Spleen and kidney Qi syndrome, dampness type, blood stasis, spleen and kidney yang were significantly (P<0.05), tibial nerve wass most evident; the level of tibial nerve Fcv was higher than normal, spleen and kidney yang significantly type> blood stasis> dampness type> Spleen and kidney Qi syndrome, the difference is significant.(P<0.05). spleen and kidney yang significantly type and Spleen and kidney Qi syndrome tibial nerve Fdlat significant difference (P<0.05),spleen deficiency was longest, spleen qi deficiency shortest.Conclusion:There are differences in neurophysiological check among different chronic renal failure Peripheral neuropathy TCM syndrome, The test data of MCV, SCV, CMAP amplitude, SNAP amplitude and the tibial nerve Fdlat, Fcv between the various TCM syndromes are significant differences. Electromyograph examination is an sensitive indicator to observe Peripheral neuropathy electrophysiological change in chronic renal failure and it probably will be one of the objective reference index of chronic renal failure peripheral neuropathy TCM syndrome research and intervention, which is worth further study and promotion.