Effects Of Rocuronium On Gastric Insufflations Related To Facemask Ventilation In General Anaesthesia Patients

Object:To explore the effect of rocuronium on gastric insufflation related to facemask ventilation in general anaesthesia patients.Methods:80 patients from june to october 2015 undergoing elective operation under general anaesthesia at Ningbo NO.2 hospital, ASA I or Ⅱ grade, aged 18-65, were enrolled in this study and divided into two groups(n=40):Group R(rocuronium) and Group C(for control). Facemask pressure-controlled ventilation (FMV) was started after general anaesthesia induced with propofol and remifentanil for a 2-min period while gastric insufflation was detected by ultrasonography of the antrum. All the patients were divided into four subgroups according to the gastric insufflation:R+, R-, C+, C-.The cross-sectional antral area(CSA) was measured using ultrasonography before and after facemask ventilation. Respiratory parameters were also recorded.Results:Compared to the antral area before FMV, the CSA significantly increased in group R and C after FMV(post-FMV:579.5±167.3,508.1±112.2; pre-FMV:479.4±110.2, 451.2±103.4; t=5.938,4.302, P<0.001). there were significant increases in the values of CSA before and after FMV in groups R+and C+(post-FMV:647.7±150.6,546.2±121.1; pre-FMV:501.2±113.6,422.6±101.5; t=7.885,8.719, P<0.001), without any significant increase in groups R-and C-(post-FMV:496.0±150.9,489.8±105.1; pre-FMV:452.9± 102.8,465.0±103.3; t=1.793,1.663, P>0.05). Compared with the group R-, the CSA of group R+significantly increased before and after FMV(group R+:146.6±87.2; group R-:43.1±102.1; t=3.458, P<0.001); Compared with the group C-, the CSA of group C+ significantly increased before and after FMV(group C+:123.6±51.1; group C-:24.8±77.4; t=4.172, P<0.001); There was no significant difference between the difference value of CSA in groups R+and C+ before and after FMV(t=0.983, P>0.05). The incidence of gastric insufflation was 55% and 32.5% in group R and C respectively(χ2=4.114, P<0.05). There was no significant difference in respiratory parameters between group R and C.Conclusions:Our study suggests that rocuronium may promote gastric insufflation related to facemask ventilation(15 cmH20 PCV)in general anaesthesia patients.