| Objective:To investigate clinical characteristics of cryptococcemia patients under different immunological status.Methods:A retrospective study was carried out to analyze the medical records of 50 patients which were confirmed diagnosis with cryptococcemia in the First Affiliated Hospital of Zhejiang University School of Medicine between December 2002 and March 2014. According to patients’immune status, they were divided into two groups: immunocompromised group (41 cases) and immunocompetent group (9 cases). This research analyzed patients’sex, age, clinical manifestation, laboratory examination, antifungal drugs and curative effect.Resultsddd:A total of 50 patients were selected, with 30 males and 20 females, and the average age was 49±17.0 years old (ranged from 15 to 83 years). 43 patients had different degrees of fever. There was no difference between this two groups in gender, age, average hospitalization time, clinical manifestation, white blood cells, neutrophils ratio, C-reactive protein and urea nitrogen. The rate of complying with cryptococcal meningitis in immunocompromised group was higher than that in immunocompetent group. Ten patients died during hospital stay,13 patients’ condition deteriorated, while 27 patients got better.Conclusion:The clinical manifestations of cryptococcemia is not typical. Cryptococcemia is more likely to occur in immunocompromised group than in immunocompetent group. Immunocompromised group are more likely to comply with cryptococcal meningitis and pulmonary cryptococcosis. The prognosis of cryptococcemia is poor. |
PDF Full Text Request