A Case Series Of 196 Patients With Neonatal Hypoglycemia

Objective: The overarching purpose of this study is to learn the epidemiological characteristics and clinical characteristics of neonatal hypoglycemia in a hospital of Changchun city. By analyzing the contributing factors of severe hypoglycemia newborns, the study explores the related factors of neonatal hypoglycemia complicated with brain, heart, liver and other organs, and the related factors which can contribute to the prognosis of neonatal hypoglycemia. It ultimately aims to enhance the clinical doctors’ understandings of neonatal hypoglycemia, improve the diagnostic level, and mitigate the harms of neonatal hypoglycemia.Method:Drawing on the retrospective research method, this study collected all cases of neonatal hypoglycemia from September 2010 to September 2015 in a hospital, information about children patients, and their parents, information about diseases and accessory examination,and fill out the form.Epidata software was used to set up the database and all collected data were analyzed using SPSS18.0Univariant and multivariant logistic regression analyses were runto examine the contributing factors of neonatal hypoglycemia and neonatal hypoglycemia complicated with brain, liver, heart,and sequela.Result:(1)A total of 196 cases of neonatal hypoglycemia were sampled. The average day-age was 4.88±7.79 days, and the cases under the age of 3 days were the most with 129 cases(65.8%) and the incidence of male children(109 cases/ 55.6%) was a little higher than that of female children. The children patients’ birth weightswere 2.93±0.78 kg on average,with 106 cases(54.1%) between 2.5~4.0 kg and only 3 cases(1.5%) under 1.5 kg.(2) A total of 117(90.3%) children patients’ mothers were under the age of 35,and 15(7.7%) mothers suffer gestational diabetes mellitus.(3)There were 56(28.6%) children patients whose blood glucose value on admission is below 1.1 mmol/L. 80(40.8%) of the children patients had the time of correcting blood glucose within 12 ~24 hours;the cases complicated with cerebral lesion, hepatic lesion, myocardial lesion were 116(59.2%)﹑100(51.0%)and 116(59.2%), respectively. There were 100(51.0%) cases with sequelae after treatment and 96(49.0%) cases without sequelae.(4)The proportion of sever neonatal hypoglycemia occuring dyspnea, cyanosis, coma, convulsion, hypoergy to heel stimulation, muscle hypotonia and hypertonia, was higher than that of mild neonatal hypoglycemia. Patients with neonatal asphyxia and the ones had a higher proportion of sever neonatal hypoglycemia(P<0.05).(5)The proportion of cerebral lesion was higher in patients whose birth weights was greater than 4.0kg, blood glucose was lesser than 1.1 mmol/L, and the time of correcting blood glucose was longer than 24 hours(P<0.05). Patients with neonatal asphyxia and the ones whose mother had gestational diabetes mellitus had a higher proportion of cerebral lesion(P<0.05). The proportion of hepatic lesion and myocardial lesion was higher in patients whose blood glucose was lesser than 1.1 mmol/L, and the time of correcting blood glucose was longer than 24 hours(P<0.05). The proportion of sequelae was higher in patients whose blood glucose was lesser than 1.1 mmol/L, and the time of correcting blood glucose was longer than 24 hours. Patients with congenital heart disease and the ones whose mother had gestational diabetes mellitus had a higher proportion of sequelae(P<0.05).Conclusion:1. Neonatal hypoglycemia often happens within three days after children’ birth.2. Neonatal asphyxia is the risk factors, which result in severe hypoglycemia. Hemoglobin over 200g/L is the protective factor, which avoids severe hypoglycemia. 3. The time of correcting blood glucose over 24 hours and lower blood glucose value are risk factors for the damaged vital organs. The time of correcting blood glucose over 24 hours and birth weight over 4 kilogram are the risk factors, which related with cerebral lesion. The blood glucose less than 1.1mmol/L is a risk factor, which related with hepatic lesion and myocardial lesion. 4. The time of correcting blood glucose over 24 hours and blood glucose value less than 1.1mmol/L are risk factor for sequelae.