Sedative And Analgesic Efficacy And Safety Of Dexmedetomidine For Postoperative Children

Objective:To evaluate the sedative & analgesic efficacy and safety of dexmedetomidine for post-operative children in pediatric intensive care unit.Methods:95 patients were enrolled and divided into 3 groups by random numerical table.They were treated with dexmedetomidine 0.3 mmg·kg-1·h-1 (group D1:31 cases、dexmedetomidine 0.6 mmg·kg-1·h-1 (group D2:32 cases)and midazolam(MID) 5 mmg·kg-1·min-1 (group C:32 cases)r All the sedatives were given intravenously with sufentanil for analgesia. Recorded the dose of analgesic,FPS scole, Ramsay scole, ventilation time, vital signs, blood gas analysis, population of contemporary sedation drugs and incidence of side effects in 12 hours after operation (at 1h,4h,8h,12h).Results:At 12h, The sedative satisfaction in group D2 is higher than in group C.There is no significant difference in the analgesic satisfaction among 3 groups. The dosage of sufentanil in group D2 and D1 are less than group C;The population of contemporary sedative in group D2 is minimum among the 3 group while it is maximum in group C. There were no significant difference in vital signs and blood gas analysis in each group.The incidence of side effects in group D2 is less than group C. The duration of ventilation in group C lasts longer than in group D1 and group D2.Conclusion:The sedative efficacy and safety of dexmedetomidine is equal with midazolam. Dexmedetomidine also shows additional analgesic activity and less respiratory depression than midazolam.It benefits in reducing dosage of analgesic, decreasing the incidence of side effects and shorten the ventilation duration. We recommend the dosage of Dexmedetomidine 0.6 mmg·kg-1·h-1,which is more reliable and durable.