| Context:Infection with Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of various malignant diseases. Not withstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results.Purpose:To obtain a reliable estimate of the risk of H. pylori infection in causing pancreatic cancer, by performing a meta-analysis of the existing observational studies evaluating the association.Methods:Observational studies comparing the prevalence of H. pylori infection in patients with pancreatic cancer and healthy controls were identified through systematic search in the MEDLINE and EMBASE. H.pylori infection was confirmed by serological testing using an antigen-specific enzyme-linked immunosorbent assay. This study further the correlation between CagA positive and pancreatic exocrine pancreatic cancer performed a subgroup analysis Pooled adjusted odds ratios (AOR) and associated 95% confidence intervals (CI) were obtained by using a DerSimonian and Laird random-effects model.Results:Six studies involving a total of 2,335 cases met our eligibility criteria 822 cases of patients group,1513 cases of the control group. A significant association between H.pylori seropositivity and development of pancreatic cancer (AOR 1.38,95% CI:1.08-1.75; P=0.009) was seen. No significant association was seen on pooled analysis of the three studies assessing the relationship between CagA positivity and pancreatic cancer.Conclusions:The pooled data suggests an association between infection with H.pylori and the development of pancreatic cancer. Further research is needed to confirm our findings. |
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