Synthesis Of The Side Chain Of Vitamin E

Objective:To improve synthesis of isophytol.Methods:5-chloro-2-pentanone ethylene ketal, the key intermediates was synthesized through Claisen Schmidt condensation reaction, Halogenation reaction and Ketalation reaction from γ-butyrolactone; 6-methylhept-5-en-2-one was obtained through Grignard reaction, Carroll rearrangement from acetone, and then reacted with 5-chloro-2-pentanone ethylene ketal to form farnesylacetone by Grignard reaction twice. Finally, isophytol was obtained by catalytic hydrogenation and Grignard reaction once again.Results:Explored a new method to synthesize isophytol, the target product and key intermediates were characterized by MS and 1H-NMR.Conclusion:The improved synthesis was benefit from simplicity of ope-ration, mild conditions, and could be suit for industrial manufacturer.