Role Of Procalcitonin In The Diagnosis Of Urinary Sepsis

Objective To study the clinical significance of PCT (Procalcitonin, PCT) in the diagnosis of urinary sepsis.Methods Totally 41 patients with urinary sepsis and 79 patients with urinary tract infection were included in the study. The levels of PCT, hypersensitive C-reactive protein, (hs-CRP), white blood cells (WBC) and neutrophil levels were detected in both groups. Receive operating characteristic (ROC) curve was drawn to evaluate the ability of PCT and related inflammatory parameters in assessing risk factors in patients with urinary sepsis, The correlation between PCT and hs-CRP, WBC and neutrophil was analyzed.Result Compared with those of patents with urinary tract infection, the levels of PCT(ug/L)、hs-CRP (mg/L)、WBC(×109/L) and neutrophil(×109/L) were significantly higher (PCT:3.113±1.953 vs.0.057 ±0.0550, hs-CRP:18.82±15.460 vs.7.440±14.52, WBC:12.860±4.002 vs.8.15±4.63, neutrophil:90.335±3.975 vs.74.30±15.40), with statistical significance(all P＜0.05), ROC curve displayed that area under the curve(AUC) of PCT was 1. higher than those of hs-CRP,WBC and neutrophils, (0.813,0.875,0.984,respectively), When PCT was 2.000 ug/L the sensitivity was 90.2% and specificity was 100%, better than those of other traditional markers of inflammation. Bivariate correlation analysis showed that a positive correlation was found between PCT and WBC and neutrophil (rs=0.609, P=0.000; rs=0.0570, P＝0.000), and there was correlation between PCT and hs-CRP (rs=0.213, P=0.02).Conclusions Serum PCT is a reliable measurement for the early diagnosis of urinary sepsis with high sensitivity and specificity. And it is conducitive to the early diagnosis and treatment of urinary sepsis.