The Effect Of A Single Intravenous Injection Of Oxycodone Hydrochloride During Cesarean Section

Objective:To observe the effect of a single intravenous injection of oxycodone hydrochloride during cesarean section on dragging pain and on short-term postoperative analgesia, and make a comparison with fentanyl.Methods:The clinical trial was performed on 60 patients who were cadidates for elective cesarean section.The patients,ASA I-II,aged 18-35, 150-170 cm tall,50-90 kg weight,were randomly assigned into three groups:oxycodone injection group(group O,n=20),fentanyl injection group(group F,n=20)and the control group(n=20).CSEA was performed on these patients,and the sensory block height was adjusted to T6-T8.Immediately after clamping the umbilical cord,patients in group O received 0.1mg/kg IV oxycodone(diluted into 10 ml with normal saline),patients in group F received 1ug/kg IV fentanyl(diluted into 10 ml with normal saline),and the control group received 10 ml normal saline. 50 mg IM meperidine was administered if necessary for severe pain relief after operation.Record the patients’ general situation(height,weight,age),operation time;observe the MAP、HR、Sp O2 both before and 5,10 min after drug administration,and at the end of the operation;record the dragging pain grading during operation;record the VAS of both incisional and uterine contraction pain at 1h(T1)、2h(T2)、3h(T3)、6h(T4)after operation;record the amount of meperidine administration and the incidence of adverse effects.Results: No significant differences were found among the three groups in general situation、operation time and MAP、HR、Sp O2 at different time(P>0.05).Compared with control group,dragging pain was lower in other groups,and group O is lower than group F(P<0.05),further more,3 patients in the control group suffered from moderate dragging pain,while nobody experienced moderate or severe dragging pain in other groups. There were no significant differences in incisional and uterine contraction pain between group F and the control group,while group O provided a lower VAS score of incisional pain at T2、T3(P<0.05). The VAS score of uterine contraction pain in group O was lower at T1 compared with the control group,and was lower at T2、T3 compared with both group F and the control group(P<0.05). No significant differences were found among the three groups in the amount of meperidine administration.Drowsiness was observed in more cases in group F and group O than the control group(P<0.05).Other adverse effects showed no significant differences.Conclusion: a single intravenous injection of both oxycodone and fentanyl can reduce the dragging pain during cesarean section,and oxycodone is superior to fentanyl. A single intravenous injection of oxycodone can reduce incisional and uterine contraction pain in a short time after cesarean section,but can’t reduce the amount of meperidine administration.