Relationship Between Lipid Levels And The Degree Of Coronary Stent Intimal Hyperplasia

Objective: To explore the relationship between blood lipid levels and the degree of intimal hyperplasia after coronary stent implantation.Methods: Patients diagnosis with coronary artery disease(acute coronary syndrome, unstable angina pectoris) enrolled in cardiovascular department, the First Hospital of Jilin University from January 1th to 31 th in 2015. Selectivepercutaneous coronary intervention(PCI)were reviewed for analysis.The patient’s history age, gender, risk factors for the coronary heart disease(with or without diabetes, hypertension, smoking history), history of previous myocardial infarction,clinical diagnosis, following-up interval, the kinds of statins, statin’s dose, duration of treatment, the length and diameter of coronary stent were recorded.Clinical relevant data and biochemical results in hospital were collected. Based on intimal hyperplasia they were divided into the mild, moderate and severe groups, rank sum test and chi square test were used for the statistic analysis of gender, age, hypertension and blood lipid level.Finally, the negative log-log regression model was used to analyze the influencing factors of intimal hyperplasia in the coronary artery stent. ROC curve was drawn based on the measurement data and degree of stent stenosis.Results: A total of 553 cases were selected, which included the mild group 288 cases(52.1%), the moderate group 175 cases(31.6%),and the severe group 90 cases(16.3%).Overall, there was no statistical significance among the history of hypertension, diabetes mellitus, history of previous myocardial infarction, emergency surgery, and the diagnosis of myocardial infarction in the three groups(p>0.05).After comparison between any two groups and correction the related factors included hypertension, diabetes, smoking etc, we conducted multi-factor analysis.The results showed that the ratio of non HDL-C/HDL-C, total cholesterol level, smoking, cholesterol lowering and high density lipoprotein cholesterol were the independent factors influencing the intimal hyperplasia.Conclusion: 1. Lipid level and the degree in stent neointimal hyperplasia wasrelated.1.1).Lipid level, especially the ratio of non HDL-C/HDL-C and total cholesterol level when reviewed is positively related with the stent intimal hyperplasia,and it is an independent risk factor.The higher the ratio of non HDL-C/HDL-C, the more severe the intimal hyperplasia was.The higher the total cholesterol level was, the more severe the intimal hyperplasia was.1.2)In the mild hyperplasia group, the patients had the lowest low density lipoprotein, the lowest level of non-HDL-C, the highest proportion of low density lipoprotein cholesterol, and the highest proportion of patients with non-HDL-C.1.3)The degree of intimal hyperplasia was mild in patients with decreased cholesterol levels after treatment.2.The intimal hyperplasia of the stent in smoking patients is more serious.3.Interventional procedures time was positively related to the extend of intimal hyperplasia.