A Study On Oral Herbal Administration Regularity About Peripheral Neuropathy In Type 2 Diabetes Mellitus(Xiao Ke Bing Arthralgia Syndrome) In The Department Of Endocrinology Of Our Hospital

Objective:To explore the rules of TCM oral medications about peripheral neuropathy in type 2 Diabetes Mellitus(xiao ke bing arthralgia syndrome),and provide the reliable reference for its TCM prevention and treatment,based on the analysis of data collected from in-patients admitted to the Department of Endocrinology,affiliated Hospital of ChengDu University of TCM(called our hospital for short below).Methods:This was a retrospective study,408 cases were brougt into accorded with requiements. Frequency analysis was appllied to find the commonly used medicines and medicine category, clustering analysis was appllied to find medicinal pairs and cluster formulas with close interrelationship, all above methods were used to explore the regulations of chinese herbs’usage.Results:1.Basic information:The proportion of male to female was 1:1.12,the average age was 65.41years old, average couse of disease was 9.49 years,cases complicated with diabetes mellitus peripheral angiopathy were the most; 2.tongue and pulse condition.The tongue quality were mainly red, light and dark, the tongue body were mainly thin,the tongue coating were mainly thin and white, then yellow and greasy, the sublingual vein were mainly tortuosity and purple.The pulse condition were mainly Sinking, thready and string;3.Research of chinese medicine:There were 149 kinds of Chinese herbs in total, the total frequency was 5297 times. There were 29 kinds of medicines that commonly used for the treatment of DPN, accounting for 60.66% of all the used medicines, whose frequency was above 1%. There were 103 kinds of medicines whose frequency was above 10 times. Classified by effect, tonifying herbs, blood-activating and stasis-resolving herbs,heat-clearing herbs,dampness-eliminating herbs were frequently used. The natures of herbs were mainly warm,cold and flat, the tastes were mainly sweetish,bitter and pungent,the meridians mainly returned to liver,spleen,stomach, kidney and heart.20 medicinal pairs and 11 cluster formulas have been got by clustering analysis.Conclusions:1.Based on the analysis of datas from DPN patients in our hospital, Astragalus, tuckahoe, atractylodes,etc were most commonly used; 2.The most frequently used herbs classes were tonifying herbs, blood-activating and stasis-resolving herbs,heat-clearing herbs,dampness-eliminating herbs;The natures of herbs were mainly warm,cold and flat, the tastes were mainly sweetish,bitter and pungent, the meridians mainly returned to liver,spleen,lung,stomach kidney and heart. 3.20 medicinal pairs and 11 cluster formulas have been got by clustering analysis,whose effect were mostly supplementing Qi and nourishing Yin and generating body fluid, promoting qi and activating blood and resolving stasis, relieving meridians and activating collaterals and alleviating pain, strenthening spleen and eliminating dampness and resolving phlegm,nourishing liver and kidney. Tonifying and removing the evil were as the main application rules,which matched the etiology and pathogenesis features of DPN that rooted with deficiency--deficiency of qi,blood,yin and yang,branched with excess--accamulation of stasis, thermal, phlegm, dampness.