Central Mechanism Of Acupuncture In Patients With Primary Dysmenerrhea Based On PET-CT

Objectives:To observe the changes of cerebral glucose metabolism by puncturing at the acupoint for primary dysmenerrhea, and explore the central mechanism of effect of patients of primary dysmenerrhea.Methods:Between March 2014 and January 2015,6 eligible dysmenerrhea patients meeting the inclusion criteria were included in this trial. All included participants were assigned to Acupuncture group(Group A). Patients in Group A received verum acupuncture treatment which is defined as acupuncture stimulation at traditional acupoints. The obligatory point is Sanyinjiao (SP6). For group A, points were needled unilaterally in each session. Sterile, disposable acupuncture needles were obliquely inserted to a certain depth. In Group A, acupuncture needles should been evenly lifted, thrust, and rotated to get the DEQI sensation. The acupuncture treatment consisted of 20 sessions of 30 minutes’duration,7 days a session for total 3 sessions over 3 menstrual cycles. The primary outcome is pain severity of PD in 12 weeks after inclusion, second outcomes include COX menstrual symptom scale.Results:1. Between March 2014 and January 2015,6 patients were enrolled in this trial; All included participants were assigned to Acupuncture group(Group A).2. PD pain severity of VAS at baseline was 6.91±1.91 in acupuncture group, While, after 3 months pain severity of VAS in acupuncture group was reduced to 4.01±0.57. There is significant difference in the comparison between pre-and post-treatment in acupuncture group (P<0.05).3. The difference in cerebral activities before and after acupuncture treatment, the patients showed increased glucose metabolism in Temporal Supper (BA 22), Frontal Supper(BA 10),Temporal Middle(BA 20), Rolandic Open (BA48) and Precuneus (BA 30).Conclusion:1. The present study primarily shows that acupuncture therapy is evident effective for short-term primary dysmenrrhea attacks when compared to routine care. Hence acupuncture should be further recommended to patients that are willing to receive acupuncture treatment.2. The effect of puncturing at the acupoint to cerebral activities include Temporal Supper, Frontal Supper,Temporal Middle, Rolandic Open and Precuneus.