The Study On The Synergistic Effect Of Qi-lan Capsule For The Multicenter And Large Sample Prostate Cancers (Deficiency Of Qi And Blood Stasis Type) After The Castration Surgery

Objection:To observe the clinical effect of the Qi-lan capsule combined with androgen deprivation therapy treating the multicenter and large sample prostate cancers (deficiency of Qi and blood stasis type) after the castration surgery.Methods:Use the methods of stochastic、control、double-blind, choose 82 cases of deficiency of Qi and blood stasis type prostate cancers that the patients had undergone castration surgery from the teaching hospital of Chengdu University of Traditional Chinese Medicine and Huaxi hospital and Sichuan Provincial People’s Hospital.For the foundation treatment(taking androgen antagonists),at the same time,treating them with the experimental drug(Qilan capsules or placebo capsule) for two Course of treatment(six months), After the end of treatment,They were randomly divided into two groups namely experimental group (Qi-lan capsule combined androgen deprivation therapy) and control group (placebo combined androgen deprivation therapy), each gourp has 123 cases, each group was observed in TCM symptom score, LUTS score, maximal Urine flow rate (MUF) detection, and prostate-specific antigen (PSA) detection. All results are used SPSS17.0 statistical analysis, P<0.05 indicated that the difference was statistically significant.Results:In this study, the remarkable efficient rate85.97%, efficiency35.09%, the inefficiency 14.03%, comparison to the control group, the remarkable efficiency 29.36%, Efficiency42,20%, the inefficiency 28.44%, the comparison of classification efficacy and the cure rate between the two groups, the difference was statistically significance, the total effective rate between the two groups, the difference was not statistically significant. TCM clinical efficacy in 8 cases clinical controlled, accounting for 7.02%, excellence in 54 cases, accounting for 47.37%, effective in 38 cases, accounting for 33.33%, ineffective in 14 case, accounting for 12.28%, in the control group clinical controlled in 4 cases, accounting for 3.67%, excellence in 27cases, accounting for 24.77%, effective in 43 cases, accounting for 39.45%, ineffective in 35 cases, accounting for 32.11%, the comparison of syndrome classification efficacy, the clinical controlled rate and total effective rate between the two groups, the difference was statistically significant. Compared with the control group, in the TCM symptom score, LUTS score, MUF value, etc., experimental group was more effective than the control group, the difference was statistically significant. It was statistically significant for the difference of PSA values between the experimental and control group before and after treatment, but there was not statistical significance on the numbers of the PSA value improvers between the two groups after treatment..Conclusion:It was an effective therapeutic method for prostate cancer by Qi-lan capsule combined with androgen deprivation therapy after castration, and the clinic effecacy for hormonal treatment could be improved by Qi-lan capsule, which can relieve the clinical symptoms,and can not intervene effectively the change of clinical PSA values.