The Demographic Characteristics And Drug-resistance Of The Smear Positive Pulmonary Tuberculosis In Yinzhou District Of Ningbo City From 2008 To 2012

Research PurposeBy analyzing the drug susceptibility results from the Smear-positive pulmonary tuberculosis in Yinzhou District from 2008 to 2012, observed the resistance of the first-line anti-TB drugs is and predicted its tendency.The demographic features such as sex, age and household registration are variables in the analysis of the resistance. Other social and economic factors (including economic incomes and educational backgrounds) are also taken into account. To seek the effective solutions to prevents and control the drug-resistant tuberculosis for Yinzhou.Research MethodAccording to 811 smear-positive pulmonary tuberculosis patients basic information, drug susceptibility results and questionnaires to create EXCEL database. Using the SPSS 13.0 statistical to analysis.Research Results1. The researcher cultures the bacteria from 811 smear-positive pulmonary tuberculosis patients and test the drug susceptibility. According to the preliminary identification of different strains, mycobacterium tuberculosis accounts for 645 patients (79.5%), mycobacterium bovis 84 (10.4%) and non-tuberculosis mycobacterium (NTM) 82(10.1%).2. This research adopts 729 TB patients as its subjects, excluding the 82 NTM patients. The total drug-resistance rate of the subjects is 23.5% and the multi-drug resistance rate is 7.3%. The initial drug resistant rate was 19.3% and the initial multi-drug resistant rate was 3.2%,the acquired drug resistance rate was 47.2%,the acquired multi-drug resistance rate was 30.6%..The initial drug resistant rate and the initial multi-drug resistant rate all lower than the acquired drug resistance,the differences were statistically significant (P<0.05).3. There is no regular orientation in the total drug-resistance rate of anti-TB drugs used in the years 2008-2012. However, the multi-drug resistance rates in those years present a continuous increasing tendency,5.0%,7.1%,7.3%,7.5%, and 8.5% respectively.,the differences were statistically significant (P>0.05)4. Streptomycin, isoniazid, rifampicin, and ethambutol rank the top 4 anti-TB medicines as far as the total drug-resistance rate is concerned. Meanwhile, the patients with first-time treatment have significant higher drug-resistance rates than those with re-treatment (P<0.05).5. There is no significant difference in the drug-resistance in terms of household registration, sex, age and occupations in smear-positive pulmonary tuberculosis patients (P>0.05)6. Body mass index of the re-treatment patients is reversely related to the drug-resistance rate, i.e. the lower the body mass index is, the higher the drug-resistance rate is. But it has no significance (P>0.05). Economic conditions have negative correlation with the drug-resistance rate, i.e. the worse the economic conditions are, the higher the drug-resistance rate is. Still, it has no significance (P>0.05).Conclusions1. The main strain for the smear-positive pulmonary tuberculosis patients in Yinzhou District is mycobacterium tuberculosis.2. The smear-positive pulmonary tuberculosis resistant rate from high to low in the order was INH、SM、RFP、EMB.3. The drug resistance rate and the multi-drug resistance rate of the acquired patients is much higher than that of the initial patients. Thus, the acquired smear-positive tuberculosis is high-risk population of drug resistance, which requires vigilance.