| Triple negative breast cancer(TNBC) is a subtype of breast cancer, defined by the lack of immunohistochemical expression of the estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor-2 (HER-2),and characterized by highly aggressive, high malignant degree, high recurrence rate, distant metastasis and local recurrence and poor prognosis. Due to the lack of expression of ER, PR and HER-2, so its endocrine therapy and HER-2 targeted therapy effect is poor, its treatments relative to other breast cancer also corresponding is restricted. TNBC has aroused wide attention of scholars both at home and abroad at present. In this review, we discuss the new progress of the clinical treatment and research of TNBC. |
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