| Objective: Observe the occurrence of osteoporosis in elderly patients with chronic heart failure, and to analyze the factors influencing the incidence of osteoporosis in elderly patients with chronic heart failure.Methods: 150 inpatients with chronic heart failure(CHF) in the First Affiliated Hospital of School of medicine, Shihezi University were included as research subjects, including 74 cases of male, 76 cases of female, aged between 60-95 years old. Eligible patients in our department were clear diagnosis of heart failure by more than two or more attending physicians based on patient history, clinical manifestations and signs, and related auxiliary examination, diagnostic reference standard Framingham heart failure.Basic clinical data analysis, biochemical indicators, echocardiography, NT-Pro BNP, osteocalcin level were analyzed by SPSS 17.0 according to NYHA class and age respectively.Results:1.150 cases of elderly patients with chronic heart failure, abnormal bone volume were 96 cases,including 57 cases of patients with osteoporosis, decreased bone mass in patients with 39 cases, 38.00%incidence of osteoporosis. The rate of occurrence of abnormal bone in NYHA grade II, grade III and grade IV were 31.58%(18 cases), 36.73%(18 cases), 47.73%(21 cases) respectively.2.There are different cardiac function and left lumbar spine BMD difference was statistically significant,and with the increase of cardiac function, bone density decreased.3.With the aggravation of heart failure, NT-ProBNP, uric acid, cystatin C, homocysteine levels gradually increased, osteocalcin, triglyceride levels decreased, the difference was statistically significant(P<0.01).4.NT-ProBNP level was negatively correlated to the first lumbar vertebra,fourth lumbar vertebra and left femoral neck BMD(coefficients were-0.228,-0.197,-0.213 respectively, P<0.05),osteocalcin levels and fourth lumbar vertebrae, left BMD were positively correlated(coefficients were 0.264,0.236 respectively, P <0.05), uric acid and the second lumbar vertebra, and left the third lumbar BMD were positively correlated(coefficients were 0.252,0.211,0.185 respectively, P<0.05) were statistically significant.5.Logistic regression analysis showed that: risk factors for osteoporosis in women, cystatin C occurred for older patients with heart failure, and protective factors for osteocalcin.Conclusions:1.With cardiac function deterioration, decreased bone density, prone to osteoporosis in elderly patients with chronic heart failure.2.In elderly patients with chronic heart failure, women, cystatin C may be a risk factor for the OP;osteocalcin may be a protective factor in the OP. |
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