The Expression Of Peripheral Blood IL-17 In The Patientswith Acute Coronary Syndorme

Objective:To investigate the changes and clinical significance of interleukin-17(IL-17) in the patients with acute coronary syndrome.Research method:From June to September 2014 in Xiamen Heart Center,The 72 cases of patients with clinical symptoms of coronary heart disease were diagnosed by the selective coronary angiograophy(CAG) method.All of them were divided into three groups :ST-segment elevation myocardial infarction group(STEMI,n=32) 、 Non ST-segment elevation myocardial infarction group(NSTEMI,n=28)、unstable angina group(UA,n=12).And the 12 cases which were CAG normal or lesions < 50% serve as control group(C group).And gather all the patients age, sex, smoking history, history of high blood pressure, diabetes, blood fat and other general information. Use the biochip suspension chip system(Bio- plex system) test the levels of serum IL- 17,and its ralated cytokines such as IL-6、TNF-ɑ.Research results:(1)cytokine IL-17 levels in the serum of patients with coronary heart disease(CHD) were significantly higher than those in control group: STEMI(322.35±256.66)pg/ml,NSTEMI(245.38±101.49)pg/ml,UA(200.12±113.12)pg/ml, control group(16.73±2.97)pg/ml(P<0.05). The expression of IL-17 in STEMI group was also higher than UA group( P < 0.05).(2)The concentrations of IL-6 was significantly higher in patients with STEMI compared with other groups(P<0.05),the level of TNF-ɑ was also higher in patients with STEMI compared with control groups(P<0.05).(3)The level of IL-17 was positively correlated with left ventricular end diastolic dimension(LVED)(r=0.2812,P<0.01),but negatively correlated with left ventricular ejection fraction(LVEF)(r=-0.3023,P<0.01).There was not correlation between the level of IL-17 and the degree of coronary artery stenosis(r=0.073,P=0.542),also no significant correlation with the number of complex lesions(r=-0.167,P=0.161).Conclusion:IL-17 may play a critical role in the immune inflammatory reaction of coronary heart disease,and there may be relationship between the expression of IL-17 and the change of cardical function after acute coronary syndrome.