Clinical Research Of C-kit And PAR-2 Expression Levels In The Skins Of Patients With Riehl’s Melanosis

Objective:To detect the C-kit and PAR-2 expression in the lesions of Rieh’s Melanosis,analysising the expression level of differential in Riehl’s Melanosis lesions and normal skin tissues,exporing both role in the pathogenesis.Methods:Selection in shanxi medical university first hospital dermatology clinic diagnosed by clinical and pathological Riehl’s Melanosis lesion group 20 cases. The first hospital of shanxi medical university orthopaedic healthy controls abandoned healthy skin tissue 20 cases. Were studied by using SP Immunohistochemical method. To determination of the gray value analysis on dyeing results.Results:C-kit in Riehl’s Melanosis lesions is mainly expressed in the melanocyte membrane of stratum basale and expression in the riel melanosis skin tissues level was high than the normal group.PAR-2 is mainly expressed in the nucleus of keratinocytes, and expression in the riel melanosis skin tissues level was high than the normal group.There is significant difference in expression of C-kit、PAR-2 in Riehl’s Melanosis lesions and normal skin tissues(C-kit:t=4.86, P<0.05;PAR-2:t=2.93, P<0.05).Conclusions:1.The expression of C-kit in Riehl’s Melanosis lesions is higher than the normal skin tissues.Its mean the synthesis of melanin is active in Riehl’s Melanosis.It may through adjust the melanin synthesis to participate in the pathogenesis.2.The expression of PAR-2 in Riehl’s Melanosis lesions is higher than the normal skin tissues.In Riehl’s melanosis, melanin from melanocytes to keratinocytes of distal dendritic transport is enhanced.It may play a role in influence the melanin transfer process and participate in the skin inflammatory reaction.