Effect Of RhGM-CSF On Healing Of Chronic Cutaneous Wounds Among Middle-aged And Elderly DM Patients

Objective:To observe and evaluate the clinical efficacy and safety of topical application of rh GM-CSF on chronic cutaneous wounds among middle-aged and elderly DM patients.Methods:Randomized controlled open clinical trial design was adopted, a total of 40middle-aged and elderly patients who had chronic cutaneous wounds were selected in First Hospital of Shanxi Medical University from 2013-03 to 2013-11. All cases were assigned by stratified random grouping method to two groups, experimental group and control group with 20 cases in each. Experimental group: rh GM-CSF with Vaseline gauze treatment group; Control group: Vaseline gauze conventional therapy group. The two groups had been followed up and observed for 8 weeks. Observe and assess each group dressing the wound exudates amount, color and wound granulation tissue and epithelial growth, adverse reactions recorded occurrence of the two groups after treatment, eight weeks after the statistical treatment of wound healing rates between the two groups, there is efficiency. The wound area and adverse reactions was recorded, and the amount of exudates, color, granulation tissue growth and epithelization in wound were observed at every dressing change time points. The wound healing rate at each time point, and the wound completely healing rate as well as efficacy rate after eight weeks of treatment were evaluated.Results:There was no statistically significant difference in wound color, granulation tissue growth and epithelialization in the four groups before the start of treatment(P>0.05).While those displayed a improving tendency during the treatment, and were statistically significantly different among the four groups from three to eight weeks after the treatment(P<0.05).Conclusion:Topical application of rh GM-CSF had Obtained the good curative effect. The treatment can expedite the formation of granulation tissue and reepithelialization of chronic cutaneous wounds among middle-aged and elderly DM patients, thus promoting the wounds to repair, which would be helpful to improve the compliance of patients, and raise their quality of life and care. And no adverse reaction occurred during the treatment course. Topical treatment of rh GM-CSF is highly effective, safe and reliable for the non-surgical treatment of chronic cutaneous wounds among middle-aged and elderly DM patients.