Expression And Significance Of Glucosylceramide Synthase In Colorectal Carcinoma Tissues

Objective To investigate the impression of glucosylceramide synthase(GCS)in colorectal carcinoma tissues.Methods Immunohistochemical method was used to detect the expression of GCS in 188 cases of colorectal carcinoma tissues and 80 cases of non-cancerous colorectal tissues. The expression of GCS and the relation with age, gender, tumor location, Tumor stage, differentiation, lymph node metastasis were analyzed. Thus, we further discussed whether to accept neoadjuvant chemotherapy can affect the expression of GCS. 122 cases of the colorectal carcinoma patients who were untreated before operation received clinical followup at a median of 39.8 months(range, 13–44months).Results GCS was overexpressed in colorectal carcinoma tissues compared with non-cancerous colorectal tissues; the expression of GCS was associated with lymph node metastasis, but not associated with age, gender, tumor location, differentiation and Tumor stage. What’s more, the positive expression rate of GCS in patients who receiving neoadjuvant chemotherapy was higher than that in untreated patients. There was no statistical significance in the relationship between GCS expression and OS and DFS(P>0.05).Conclusion GCS was upregulated in colorectal carcinoma tissues. It might not only play an important role in controlling the generation and progression of colorectal carcinoma, but also be a factor of MDR.