The Preparation And Evaluation Of Trichloroiminocyanuric Acid Effervescent Tablets

With the improvement of people’s health awareness, people have considered the good health environment as a prerequisite in many ways such as life, work or food, etc. As a new disinfectant, Trichloroiminocyanuric acid(TCCA) possesses the characteristics of high efficiency, broad spectrum and safety, and it can be used in disinfecting water environment, equipment, instruments and public places. As a consequence, the domestic and foreign requirement is rising gradually. However, TCCA has strong oxidation and chlorination. It’s easy to decompose in acid and alkali, likely to explode when catching up with ammonia and ammonium substance containing ammonia, ammonium sulphate and urea, and unable to be mixed with the oxidant or the reductant, therefore its storage condition is strict. Effervescent tablets is a kind of dosage of tablet which has many advantages, such as small volume, convenience and quick effect. Prepared TCCA into effervescent tablets can play a great help to its use, storage and transportation.On the basis of fully understanding TCCA’ s physical and chemical properties, characteristics function and application direction, at the same time, knowing well about the characteristics, required materials, technology and evaluation indicator of the effervescent tablets, the present paper mainly includes:①The alternative adjuvant fitting the TCCA have been chose: the fillers are water-soluble starch, cane sugar, glucose, boric acid, the disintegrants are tartaric acid, anhydrous citric acid, sodium bicarbonate, the binders are sdium carboxymethylcellulose(CMC-Na), polyvinylpyrrolidone(PVP), the lubricants are sodium dodecyl sulfate(SDS), polyethylene glycol6000(PEG6000), sodium chloride. According to the compatibility research between TCCA with adjuvant and between different adjuvant, the feasibility of alternative adjuvant has been confirmed. Next, after single factor experiment, choose the glucose as filler, tartaric acid and anhydrous citric acid mixture as the acid, sodium bicarbonate as the base, CMC-Na as the binder, SDS as the lubricant. At last, according to orthogonal design, the supplementation of glucose is 10%, the proportion of anhydrous citric acid and tartaric acid is 1:2, the proportion of acid and base is 1:1.②The preparation technology of TCCA effervescent tablets and the influence factor in preparation including drying temperature and drying time, the humidity of external environment, the water content on granule, the amount of binder, the amount of lubricant have been researched. The results shows that the granulation with separated the acid and base is better, the humidity of external environment should be under 40%RH, the water content on granule between 0.32%~0.67%, the binder of acid is 2%CMC-Na and the dosage is 95 ml, the binder of base is 1%CMC-Na and the dosage is 100 ml, the added content of lubricant is 1%.③The quality and property of TCCA effervescent tablets have been evaluated. The results show that the weight variation, disintegration time, p H, hardness, friability, foam volume all up to the standard of Chinese Pharmacopoeia. The stability research shows that when during the storage, it had best keep out of the light, and the temperature and humidity of external environment should be low. The result of available chlorine content of TCCA effervescent tablets research shows that the TCCA effervescent tablets have stable property and up to the standard of content stability.