| Objective: The objective of this thesis is to detect the pregnant woman cervical- vaginal secretions of fetal protein fiber connection(f FN) and the positive rate of B group hemolytic streptococcus(GBS), the concentration of fetal fiber link protein(f FN), and to investigate the relationship between GBS, FFN and preterm premature rupture of the membranes(PPROM),the association between them, also to investigate the impact of GBS infection in pregnancy on maternal and neonatal outcomes.Methods: The author selects 90 cases of pregnant women who have been in the hospital(Department of Obstetrics Affiliated Hospital of Yan’an University), 30 cases of which are 28-36+6 weeks premature rupture of membranes pregnant women whose rupture time is 6-170 hours; 30 cases of premature rupture of membranes pregnant women in 37-40 weeks whose rupture time is 5-48 hours; and another 37 to 40 weeks of 30 cases of normal childbirth pregnant women, who are 18 to 35 years old. The-maternal age, gravidity of the three groups are no significant differences. The pregnant women don’t have surgical complications and other pregnancy complications in the past(such as gestational hypertension, excessive amniotic fluid, fetal distress, and cord prolapse), no recent history of the use of antibiotics, infection history and other factors, the-vaginal secretions contaminated blood to be excluded. Forward light method is used to detect f FN of 90 cases of pregnant women cervical- vaginal discharge concentration; Bacterial cultivation method is used to test 90 cases of pregnant women in the vagina secretion under 1/3 of positie GBS and GBS positive maternal, also the author compares newborn and negatie and investigates the effects that GBS infection has on mother and child outcome.Results: 1. The inspection of GBS, f FN in three groups of pregnant women cervix- vaginal secretionsIn this study of 90 cases of pregnant women selected, there are 14 cases of GBS positive, among of which the positive rate of PPROM group is 26.67%(8/30), the positive rate of premature rupture of membranes group is 20.00%(6/30), the normal group doesn’t cultivate the GBS. The GBS positive rate of Premature rupture of membranes group is significantly higher than the normal group(x2= 9.23, 6.67, P <0.01), and the difference has the statistical significance; Also the author compares the positive rate in PPROM group and PROM group(x2= 0.37, P> 0.05), but the differences doesn’t have the statistical significance. The f FN positive rate in PPROM group, premature rupture of membranes group and the normal group are: 100%, 93.33%, 73.33%. The comparison of positive rate between Premature rupture of membranes and PPROM group(x2= 0.52, P> 0.05) shows that the difference doesn’t have statistical significance; The comparison between PPROM group, premature rupture of membranes group and the normal group(x2= 7.07, 4.32, P <0.05) shows that the difference doesn’t have statistical significance. The average concentration of f FN in PROM group and normal delivery group are: 158.30±124.11,250.49±301.23. The comparison of average concentration between PPROM group and the normal group(t =-0.895, P> 0.05) shows that the difference doesn’t have statistical significance. 2. The bad impact that the GBS-positive patients and GBS-negative patients have on maternal and neonatal outcomes. The chorioamnionitis in GBS-positive concludes 10 patients(71.43%), 6 cases of fetal distress(42.86%), and 3cases of postpartum hemorrhage(21.42%). In GBS-negative, there are 13 cases of chorioamnionitis complications(17.11%), fetal distress in 11 cases(14.47%), and 10 cases of postpartum hemorrhage(13.16%). The chorioamnionitis and fetal distress in GBS-positive group are significantly higher than GBS-negative group(x2=18.34, P <0.01; x2= 4.50, P <0.05), the difference doesn’t have statistical significance; and postpartum hemorrhage in two groups(x2=0.41, P> 0.05), the difference doesn’t statistically significance either. In the GBS-positive group, there are 9 cases of the neonatal asphyxia, 11 cases of neonatal pneumonia(78.57%)and 10 cases of Jaundice(71.42%); Neonatal in GBS negative group appears 21 cases of neonatal asphyxia(27.63%), 24 cases of neonatal pneumonia(31.58%), 18 cases of jaundice(23.68%). The incidence of neonatal asphyxia in GBS positive group is higher than in GBS-negative group(x2=5.59, P<0.05), and the difference doesn’t havestatistical significance; Also the incidence of Neonatal pneumonia and Jaundice in GBS-positive is higher than GBS negative group(x2= 10.99,10.68, P <0.01), the difference doesn’t have the statistical significance. 3. The difference in the f FN average concentration of premature rupture in membranes group and the normal group. The average concentration of f FN in premature rupture of membranes group is 158.30±124.11; The average concentration of normal group is 250.49±301.23. The comparison of average concentration between membranes group and the normal group shows that the difference doesn’t have statistical significance. 4. Correlation between GBS and f FN in cervix-Vaginal secretions of Premature rupture of membranes group of pregnant women After matching four table of chi-square test, the author analyses the correlation coefficient(r = 0.43, P <0.01) of GBS and f FN in premature rupture of membranes(PPROM) before term premature rupture of membranes and group pregnant women cervical vaginal secretion, and the difference has statistical significance.Conclusion: 1. Three groups of pregnant women cervical- GBS positive rate, f FN positive rate in vaginal secretions differences have statistical significance, therefore, GBS infection can lead to premature rupture of membranes before term occurs, and there is a close relationship between them. Meanwhile, FFN positive hints may occurs PPROM, and premature rupture of membranes at term group and normal group may be about to go into labor. 2. Premature rupture of membranes, chorioamnionitis, preterm delivery, fetal distress, neonatal asphyxia, jaundice is associated with GBS infection, which has a great influence on the maternal and neonatal 3. In Premature rupture of membranes in pregnant women cervical vaginal secretion, f FN were positively correlated with GBS... |
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