Arterial Spin Labeling Analysis Early Brain Perfusion Change Research After Acute Drinking

Objective:By three-dimensional arterial spin labeling technology(3 d- ASL)on acute alcohol after early brain perfusion(CBF) quantitative change, preliminary analysis of the influence of perfusion of acute alcohol, recognizing drunk perfusion change contact between brain function.Materials and methods:80 healthy volunteers were divided into trial group and the placebo, 40 people in each group(20) men and women, average age 25.2±2.7years old.All the volunteers had no personal and family history of alcoholism, mental history of drugs and drug use.Both groups except regular scans brain lesions, the experimental group on an empty stomach some liquor concentration(50%), 1 ml/kg each time, the control group on an empty stomach amount of placebo(amount of pure water), 3.0 THdxT mri scanning equipment by GE.Two groups before the test are scanned for ASL as a baseline, 20 minutes after drinking then test group accepted ASL scanning, were performed before each check blood alcohol concentration and physiological indexes of monitoring.The data was analyzed by SPSS 20.0 statistical software, group in comparison with paired t test, comparison between the two groups using independent sample t test.The control group and experimental group perfusion values no statistical difference before drinking, left, right brain perfusion values within two way had no statistical difference. The control experiment before and after brain perfusion changes without statistical significance. 21 people among the experimental group 40(12 male and 9 female) in the cerebral cortex, the thalamus and lentiform nucleus, the cerebellum, medulla oblongata of perfusion increased(P<0.05), brain regions compared to left and right are all no statistical significance(P>0.05), of which 12men’s frontal cortex perfusion changes the most significant, while women are characterized by increased total cerebral perfusion diffuse. This 21 volunteers becomes more excited for the mood, language, easy to laugh, increased physical activity, feeling, five volunteers appeared dizziness and blurred vision. The other 11people(male 8 female) occipital lobe, cerebellum and the medulla oblongataperfusion decline, have statistical significance(P<0.05), of which the occipital lobe perfusion change is most obvious, the 11 volunteers are dizziness, blurred vision,such as unstable posterior circulation suppression of brain areas and the corresponding performance. Left and right hemispheres are perfusion change no statistical difference. 21 perfusion of the thalamus(12 male and 9 female) volunteers clearly upward trend in the early drinking, but rising amplitude varies from person to person, was not observed in the experiment because the thalamus perfusion increases with the appearance and function of these volunteers stimulated corresponding behavior change, phase in which four volunteers(2 men and 2 women) in the skin temperature touch down. Experiments found that the basal ganglia region of the nucleus accumbens perfusion values show some differences. The nucleus head and shell back drinking nuclear perfusion increased significantly, and the highest degree in caudate head perfusion increased, and pallidum perfusion after drinking alcohol is still lower than other nuclei, this may be associated with basal ganglia region vascular distribution, left and right basal ganglia region perfusion change no statistical difference. 6(5 male 1 female) brain perfusion and drinking before the basic same, no statistical significance(P>0.05). 2 people feel body unwell obviously after drinking out of experiment. From this experiment preliminary data for blood alcohol concentration at 60 mg/dl, brain perfusion increased overall trend, volunteers are mostly characterized by excited state, mainly for the facial blushing, breath with wine,feel cheerful(smiling,words more). But when the blood alcohol concentration of more than 60 mg/dl, circulation brain perfusion after 11 volunteers started to decline,have blurred vision, unstable, dizziness, etc.Conclusion:Finally,38 subjects showed that 21 traditionalists drink drunk, and grey matter cortical perfusion obviously higher(55.3%), 11(28.9%), more than 6people does not change significantly(15.8%), the female is in before and after drinking is higher for whole brain gray matter perfusion diffuse, and averages around10% higher than men. Suggests that alcohol can change the brain perfusion, different level especially posterior circulation supply areas of the brain, which affects brain function change. Obvious individual differences, but the change may be drunk in different mood and execution difference of important factor. Effect of alcohol on thebrain in general is to first excited, after drinking the brain’s major brain perfusion will appear with the increase of blood alcohol concentration increases after the first reduce the change, the change of inflexion points corresponding to the blood alcohol concentration varies from person to person, at the same time of behavior, language,and physiological indexes change are also different.