The Correlation Between REM Sleep Behavior Disorder&subclinical REM Sleep Behavior Disorder And Cognitive Function In Patients With Parkinson’s Disease

Parkinson’s disease(PD) is a common degenerative disease of nervous system, it appears mostly in middle-aged and old people. REM sleep behavior disorder(RBD) is a common sleep disturbance in patients with PD.Recently studies revealed that RBD has a influence on the progression and cognitive function of PD for the patients.However, the role of subclinical REM sleep behavior disorder(sRBD)remains unknown.Objective: Investigate the influence of RBD and sRBD to the progression and cognitive function in patients with PD.Methods: We assigned 53 patients with PD from the Second Affiliated Hospital of Nanchang University. For everyone, age, gender, education level were recorded.Patients with dementia were excluded.The correlative scales were assessed by the form of face to face,including Montreal cognitive function score(MoCA),Unified Parkinson Disease Rating Scale(UPDRS),Parkinson Disease Sleep Scale(PDSS),REM sleep behavior disorder screening questionnaire(RBDSQ),et al. The sleep quality was assessed by polysomnography(PSG),meanwhile PD patients were divided into RBD group(PD-RBD),subclinical RBD group(PD-sRBD) and normal REM group(PD-REM) based on the polysomnography.The progression and cognitive function were compared among the three groups.Results:1、PD patients with RBD demonstrated a significantly higher UPDRS score and Hohen- Yahr stage,while showed a larger decline in PDSS score.2、Length of PD morbidity of PD with RBD was longer than that in the PD with sRBD.(p=0.021).3、MoCA score of PD with RBD group was lower that in the PD with normal REM group.(p=0.032).4、There were no statistically significant differences in progression or cognitive function among the PD with sRBD group and PD with normal REM group.Conclusion: The presence of RBD can aggravate the condition of PD patients.RBD may be an important risk factor of the development of cognitive dysfunction in PD patients. We haven’t detected subclinical RBD was associated with the the progressive disease and cognitive dysfunction in patients with PD.It is not clear whether subclinical RBD in PD develops to RBD in all patients.It still need further researches.