A Meta-analysis Of Studies On The Association Of Platelet Glycoprotein Receptor GP Ⅱb/Ⅲa PLA1/PLA2 Polymorphism And Coronary Risk

Objective: To observe the association between GP IIb/IIIa receptor polymorphism and risk of coronary heart disease(CHD).Methods: We thoroughly and systematically searched EMBASE, MEDLINE,PUBMED databases from 1996 to august 2014 to gather all relevant published studies. Data were screened and extracted according to the Cochrane Handbook for systematic reviews. All data were analyzed by using STATA 12.0. RR was calculated on the basis of random effect model. Primary analysis on CHD and the secondary analysis on types of coronary events, ethnicity, nature of study, gender, and sample sizes were performed respectively.Results: Total 43 samples from 35 studies were recruited for the analysis comprising 14006 cases and 14682 controls. The PLA2 allele carriage was significantly associated with myocardial infarction(5119 cases and 4638 controls, RR1.10(95% CI 1.00-1.20, p=0.043) in presence of significant heterogeneity( I2=68.5 %; p=0.000), however the association was not observed in CHD( RR 1.00(95%CI 0.94-1.06, p=0.917).The association was also significant in male patient with MI(RR 1.26, 95% CI 1.00–1.58; p=0.049).Conclusion: The association of PLA2 allele carriers with CHD in a general population was found to have statistically non significant, however the association appears to be significant in some extend when we considered MI only population and male sex.