A Meta-analysis Of The Association Of PNPLA3 Polymorphisms On The Susceptibility And Histological Severityof Non-alcoholic Fatty Liver Disease

Objective:In order to clear the strength of the effect of the patatin-like phospholipase domain containing 3( PNPLA3) rs738409 Polymorphisms on the susceptibility and disease severity of non-alcoholic fatty liver(NAFLD),and performed a systematic review by a meta-analysis.Methods:For the electronic searches, all case-control studies about the association of NAFLD and PNPLA3 rs738409 Polymorphisms were identified by searching through Chinese National Knowledge Infrastructure(CNKI)、 Wan Fang Data 、VIP Data and Pub Med up to Dec 2014.Results:65 studies were selected by the keywords, and a total of 21 studies with 14266 subjects were included. Meta-analysis showed that PNPLA3 rs738409 Polymorphisms exerted a stronger influence not only on fatty liver but also on the histological injury. PNPLA3 rs738409 [G] allele was a risk factor of NAFLD(GG vs CC: odds ratio(OR) =4.01, 95% confidence interval(95%CI): 2.93-5.49;GC vs CC: OR=1.88,95%CI:1.58-2.24).PNPLA3 gene variant was significantly associated with the increase in serum alanine aminotransferase(ALT) levels(GG vs CC:. SMD=0.47 95%CI: 0.14-0.81).In addition, Non-alcoholic steatohepatitis(NASH) was more frequently observed in [G] allele carriers(GG vs CC:OR =3.24,95%CI:2.79-3.76;GC vs CC:OR=2.14,95%CI:1.43-3.19).Conclusion:By summarizing the above evidences, this study provided that PNPLA3 rs738409 Polymorphisms not only as a factor of significantly associated with susceptibility to NAFLD,but also on the susceptibility to aggressive disease.