The Effects Of Neoadjuvant Chemotherapy On Sensitiveness With Propofol In Breast Cancer Patients

Objective To evaluate the effect of neoadjuvant chemotherapy on sensitivity with propofol in breast cancer patients.Methods fifty-six female patients with ASAⅠorⅡwho underwent elective modified radical mastectomy for breast cancer were selected in the department of surgical oncology, general hospital of Ningxia medical university tumor hospital. All patients were examined by physical palpation and ultrasound or mammography, then confirmed by hollow core needle biopsy and histopathological examination before neoadjuvant chemotherapy. We determined the stage of Ⅱ~Ⅲ period of patients with breast cancer by the examination with ultrasound, X-ray, bone scan to exclude distant metastases. According to whether undergoing neoadjuvant Chemotherapy before preoperative: neoadjuvant chemotherapy(Group C) and Non-chemotherapy group(Group NC), twenty-eight patients in each group. Propofol was infused continuously at 20mg·kg-1·h-1, and stopped when the BIS dropped to 40 from the base value, then recorded the total dosage of prorofol when induction and the blood pressure, heart rate and induction time during the BIS underwent different periods when induction.Results1. The comparison of the age, body mass indexes and the basis values of BIS, heart and mean arterial pressure in the two groups had no statistical significance(P>0.05);2. Comparing with those before anesthesia induction, both heart and mean arterial pressure of the two groups decreased significantly, but it has no statistical significance among groups(P>0.05). Compared to basis values, the values of mean arterial pressure were statistically differences in all stages of group C(P <0.05) and in other stages of group NC except T1 stage(P <0.05). The significant differences were found in heart values in T4~T6 stages of group C and in T6 stage of group NC(P <0.05);3. Compared with group C, the time for same sedative depth(BIS=90、70、50、40)were significantly shortened in group NC(P <0.05);4. The total dosage of propofol in C group(86.4±19.5) mg was less than that of group NC(101.9±19.5) mg(P <0.05).Conclusion The neoadjuvant chemotherapy can reduce the amount of propofol during induction of anesthesia, and short the time of achieving the same sedation depth. Therefore, the neoadjuvant chemotherapy can improve the sensitivity of propofol on patients who have breast cancer.