CEA And PTEN Expression In Bilateral Primary Breast Cancer

Objective: To detect the left and right sides of primary bilateral breast cancer pathology paraffin sections of CEA expression and PTEN expression and intensity differences, revealing its occurrence is independent clonal or monoclonal. Comparative analysis between the protein and the bilateral and unilateral lesions with pathologic type differential expression. Methods: Nine patients with primary bilateral breast tissue around a total of 18, corresponding with unilateral breast tissue of breast cancer patients 10. Immunohistochemistry was used to detect the expression of CEA and PTEN. Results: The first bilateral breast cancer with unilateral breast cancer and the second of CEA expression rates were 66.6%(6/9), 55.5%(5/9), 60%(6/10), PTEN in the first cancer, second cancers, the expression of unilateral breast cancer was 33.3%(3/9), respectively, 44.4%(4/9), 50%(5/10), the expression of the difference was not statistically significant(P > 0.05), with bilateral breast cancer were positive for CEA in five cases, the same as negative for the three cases, PTEN positive for the same three cases, the same as negative for the five cases. Conclusion: The significant unilateral bilateral breast cancer and breast cancer in the first expression CEA, PTEN protein no. The first bilateral breast cancer and second cancer CEA, PTEN protein expression difference was not statistically significant, suggesting that bilateral breast cancer is the first cancer and second monoclonal.