Impact Of TACE Combined With Partial Splenic Embolization On Immune Function In Patients With Hepatocellular Carcinoma And Hypersplenism

Objective:To investigate the impact of TACE alone and TACE therapy combined with partial splenic embolization for hepatocellular carcinoma with hypersplenism patient’s immune function.Methods: A prospective study of patients 66 cases of hepatocellular carcinoma with hypersplenism,sixty-six patient clinically diagnosedas hepatocellular carcinoma with hypersplenism were randomly divided into two groups: TACE groups(n=35)and TACE+PSE groups(n=31).the TACE+PSE group underwent PSE and transcatheter arterialchemoembolization(TACE). Before and after treatment, blood routine exami-nation was performed, and immunologic pa-rameters( Humoral immunity 、 Cellular immunity) were determined in both groups. Thecomplications associated with treatment were also observed. Results:In the TACE+PSE group, significant differences were noted in WBC and PLT(both P < 0.05)between before and after treatment. Significant differences were noted in WBC and PLT(both P < 0.05)after treatment,between two groups.Significant differences were noted in CD4+、CD8+lymphocyte percentage and CD4+ /CD8+ratio 7 and 30 days after treatment, between two groups.Significant differences were noted between preoperative andpostoperative CD4+ 、 CD8+lymphocyte percentage and CD4+ /CD8+ ratio in the TACE+PSE group(all P < 0.05),but not in the TACEgroup(all P> 0.05);In the TACE+PSE group,after 30 days of Ig A significant compared the preoperative data, there is asignificant differences( P>0. 05).Humoral immunity indicators: postoperative Ig G、Ig M compared with the preoperative was no significant differences( P>0. 05).There is no signifi cant difference in the incidence of complications(such as fever, abdominal pain,ascites, and pleural effusion) between the two groups(P > 0.05). Conclusion: TACE combined PSEtreatment of hepatocellular carcinoma with hypersplenism, the operation simple and safe, Can effectively alleviatehypersplenism, improve immune function, improve immunity,so there is the implementation of the selected joint interventional procedures, can achieve more satisfactory clinical diagnosis, should be widely applied.