EEG Signals Analysis And Intervention Of Transcranial Magnetic Stimulation On Children With Autism

Autism spectrum disorder(ASD) is a complicated and heterogeneous developmental disorder, involved in multiple nervous system function disorder. It is characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. The morbidity of ASD is about 88:1, and the male morbidity is 54:1. ASD exhibits incredible genetic heterogeneity. It is estimated that the probability can be reached to 70%-90%. This disorder also has a high recycling rate which is about 10%-20% in brothers and sisters according to the reliable data. However, it is very difficult to explain the etiology and pathophysiology of autism research mechanism now. Genetic and environmental factors in early development are key factors in the etiology of autism, and rare mutations and common mutations also increase the risk of autism. Therefore, it is necessary to assess the autism from the perspective of a multidisciplinary study and early detection is essential for early intervention.Many researchers have proposed a theoretical form of structural and functional brain on the basis of anatomy for specific symptoms of autism, including abnormalities in neural functional connectivity, mirror neurons system, cerebellar dysfunction and cortical functional column. The view of the abnormalities of cortical functional column may lead to impaired neural functional connectivity has been supported by more and more researchers. Repetitive transcranial magnetic stimulation(r TMS) offers a noninvasive method for altering excitability of the neural circuits and induction of a short-term functional reorganization in the human cortex. In this paper, r TMS which is painless, non-invasive brain-control techniques is utilized to treat children with ASD in behavior and social cognition. Quantitative electroencephalography(EEG) of resting-state data is collected and recorded at pre-r TMS and post-r TMS to describe the treatment outcomes.This objective of this study was to determine the effect of r TMS on children with autism by recording EEG pre- and post- r TMS. According to the results of the experiment, we found that the behavior of children with autism was improved the excess gamma(γ) power has been found reduced in absolute power, the complexity of the whole brain increased, the distribution of EEG amplitude was more uniform and the long-range coherence was improved after r TMS stimulation. These results validate some assumptions in previous and we should do more research about the effect of interventions on children with autism in the future.