The Resting-state Fmri Study Of Recruits Ajustment Disorder

Objective1.To explore the feature of baseline brain activity changes in recruits with adjustment disorder by resting-state f MRI regional homogeneity. The Re Ho values of different regions concerned between the two groups were correlated with the Self-Report Symptom Inventory, Symptom Check-List 90(SCL-90).2.Utilizing posterior cingulate cortex as seeds to define the seeding voxel to analyze the imaging data with resting-state functional connectivity.Materials and MethodsSixteen cases of recruits adjustment disorder,who were collected by combing with SCL-90 and clinical diagnosis,and sixteen matched healthy controls, while the RS-f MRI data were recorded by a Siemens3.0 T Trio MR scanner with heads in 12 channel array coil.The Resting-state f MRI data preprocessing was performed using DPARSF(data processing assistant for resting state f MRI). Regional homogeneity analysis was performed using REST software and the REST Slice View software was used to view the anatomical locations of the Re Ho differences between the two groups.Re Ho analysis estimates regional activation patterns through indices of localized concordance. The Re Ho values of different regions concerned between the two groups were correlated with SCL-90.Re Ho values were compared between groups, followed by rs-FC analysis utilizing posterior cingulate cortex as seeds to identify other involved regions by seed correlation analysis method,then the difference of functional connectivity of brain regions was recorded.Results1.Compared to controls, adjustment disorder subjects demonstrated increased Re Ho in the Posterior cingulate cortex(PCC), Precuneus(Pcu), Occipital lobe, while diminished Re Ho appeared in the cerebellum posterior, left caudate nucleus, bilateral temporal lobe, bilateral middle frontal gyrus, left thalamus, right parietal lobe(P<0.05).2. Re Ho of abnormal brain regions in cerebellum posterior lobe were negatively correlated with SCL-90 scale(r=-0.7498,P=0.013), while others did not show any significant differences(P> 0.05).3.Compared with control group, the recruits with adjustment disorder showed significantly decreased functional connectivity with PCC in the left hippocampus,precuneus, left superior frontal gyrus, medial frontal gyrus, inferior frontal gyrus,right medial temporal gyrus(P> 0.05).Conclusion1.Abnormal local brain activity might exist in recruits with adjustment disorder during resting state.2.The functional connectivity of recuits with adjustment disorder was abnormal in many areas during resting state.3. Abnomal functional connectivity with regional homogeneity and default mode network may exist in recuits with adjustment disorder during resting state.The abnormality of default mode network may play an important role in psychopathology of depression, and be helpful to explore the neural function and physiological mechanism.