Related Risky Factors Analyzed And Clinical Management Of Patients With Nasopharyngeal Carcinoma Suffered Hemorrhoea After Radiotherapy

Objective To explore the clinical measurements for preventing and curing hemorrhoea on patients who were irradiated because of nasopharyngeal carcinoma by analyzing the related risky factors.MethodsFrom January 2006 to January 2014, 1846 patients with nasopharyngeal carcinoma were received radiotherapy in Fuzhou PLA(Chinese People,s Liberation Army) General Hospital. We picked up 30 patients who were suffered from hemorrhoea after radiotherapy form the 1846 pat ients, then the 30 patients were put into a research which was retrospectively reviewed by analyzing the associated risk factors of the hemorrhoea. Detailed record included the name, sex, tumor stage, therapy method,skull base invasion, irradiation course and living habits(drinking and smoking).The tumor stage was accorded to the staging criteria of AJCCTNM. When patients suffered from hemorrhoea, postnasal packing and digital subtraction angiography selective arterial emblization were chosed to stop the bleeding, which were based on all of the clinical conditions, then we analyzed the associated risky factors of the hemorrhoea and clinical characteristics, and explored the clinical measurements for preventing and curing it.Results 1. There were no obvious reason and specific clinical manifestations before hemorrhoea.Most clinical manifestations were little amount epistaxis and headache. 2.The 26 patients of 30 received postnasal packing, the 4 adopted digital subtraction angiography selective arterial emblization.. 3. Patients who was with advanced age, later tumor stage, skull base violated and more than one irradiation course had shorter latent period(P=0.005, P=0.042, P=0.037, P=0.026) and higher amount of bleeding(P=0.001, P=0.003, P=0.041,P=0.017).Conclusion 1. As a serious disease, keeping airway unobstructed and stable vital signs and adopting timely measurements, which was the key to the successful rescue. 2.Postnasal packing and digital subtraction angiography selective arterial emblization were feasible and effective measures. 3. Patients who was with advanced age, later tumor stage, skull base violated and more than one irradiation course had shorter latent period and higher amount of bleeding. 4. Whether related to the living habits such as drinking and smoking remains to be demonstrated.