The Relevance Study Between Acute Coronary Syndrome And Gastroesophageal Reflux Disease

Objective: To examine the morbidity of gastroesophageal reflux disease(GERD) and its associated factors in patients with acute coronary syndrome(ACS).Objective: 800 subjects were enrolled at Zhongshan Hospital Xiamen University from May 2013 to March 2014, including 300 ACS cases and 500 healthy controls. All the subjects were inquired with reflux diagnostic questionnaire(RDQ), and the related factors(including gender, smoking, alcohol drinking, diabetes mellitus, dyslipidemia, BMI, hypertension, et al) were analyzed to investigate the correlation between ACS and GERD.Results: The incidence of GERD in ACS group(19.3%) was significantly higher than that in non-ACS group(9.2%, P<0.05); the GERD incidence in female of ACS group(31.7%) was higher than control group(8.4%, P<0.05); the GERD incidence in female of ACS group(31.7%) was higher than male(14.7%, P<0.05); GERD was correlated with gender, drinking, hypertension, diabetes, hyperlipidemia(P<0.05), The two category of tepwise Logistic regression analysis concludes that gender, hypertension, diabetes, high cholesterol is a risk factor for GERD in ACS group. The gender is independent risk factor of GERD in ACS group. Drinking has negative correlation of GERD in ACS group.Conclusions: There is a correlation between ACS and GERD in patients with ACS. There was a higher prevalence of GERD in ACS patients than healthy controls. The incidence of GERD in female with ACS was higher than in male or healthy people. Gender, hyperlipidemia, diabetes and hypertension, are risk factors for ACS combined with GERD. Gender is an independent risk factor of GERD in ACS group. Drinking has negative correlation with GERD in ACS group. It may be influenced by data.