| ObjectiveTo retrospectively analyze the level of serum free fatty acid(FFA) in acute pancreatitis(AP), and its relationship with gender, age, etiology, disease classification. To explore the value of FFA in AP severity assessment.Methods124 of patients with AP who were admitted to the First Affiliated Hospital of Fujian Medical University of Digestive Internal Medicine and Intensive Care Unit from July 2009 to February 2015 and 157 non-AP as controls were recruited. AP patients were divided into 37 hypertriglyceridemic acute pancreatitis(HLAP) including 18 mild acute pancreatitis(MAP) and 19 severe acute pancreatitis(SAP) and 87 non-HLAP including 59 MAP and 28 SAP. Compare the level of serum FFA between AP group and non-AP group. Analyze the various FFA levels in AP patients with different gender, age, etiology and disease severity. Explore the relationship between serum FFA level and systemic inflammatory response syndrome, APACHE II score, Ranson score, CT grading in AP patients.Results1.The FFA in non-AP,non-HLAP,HLAP patients were 464.21± 203.22 u Eq/L, 489.56± 280.89 u Eq/L,874.73±470.55 u Eq/L, respectively. FFA in HLAP group was significantly higher than that in non-AP and non-HLAP group(P<0.001). But the difference in FFA between non-AP and non-HLAP were not statistically significant(P=0.460).2. The FFA of males and females in non-AP, non-HLAP and HLAP were 456.00( 294.00-571.50) vs504.50( 354.00-672.50),490.04±261.13vs488.95± 308.11,752.43±417.36vs1035.25±500.72,respectively,which were not statistically different(P > 0.05).The FFA of age under 60 and over 60 in non-AP andnon-HLAP were 448.24±212.56vs477.06±195.67,480.92±289.77vs501.24± 271.95, respectively,which lack statistical difference(P>0.05).3. The level of FFA in SAP of HLAP and non-HLAP groups were significantly higher than that in MAP of HLAP and non-HLAP groups.They were 401.34± 241.10vs675.46±271.28(P<0.001),620.56±262.72vs1115.53±501.84(P=0.001), respectively.In addition, the average level of FFA in SAP of HLAP group exceeded the limit of the normal range.4. The serum FFA level in MAP of HLAP group was significantly higher than that in MAP of non-HLAP and non-AP groups(P=0.001,P=0.003), while FFA level in MAP of non-HLAP groups and non-AP groups were not statistically different with each other(P=0.056). The level of FFA in SAP of HLAP group was significantly higher than that in SAP of non-HLAP and non-AP groups(P=0.002,P<0.001),and that in SAP of non-HLAP was higher than that in non-AP groups(P<0.001), among which the average levels of FFA were within limit of normal range.5. There was a positive correlation between the level of FFA and SIRS, Ranson score, CT grading(P<0.05)and TG, TC, VLDL(P<0.001), while there was no correlation between FFA and age, gender, APACHE-II, the levels of LDL and HDL(P>0.05).ConclusionThe level of serum FFA was higher in SAP,and it was significantly in HLAP.Among which the serum FFA level was associated with SIRS, Ranson score, CT grading, suggesting that it may be used as a biomark to evaluate the severity of AP, especially of HLAP. |
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