The Clinical Analysis Of Non Functional Pancreatic Neuroendocrine Tumours

Objective:To summary and explore the diagnostic and surgical therapeutic characteristic of non functional pancreatic neuroendocrine tumours, than have a good understanding. Methods:The clinical data of 16 patients with non functional pancreatic neuroendocrine tumours confirmed by pathologic examination were analyzed retrospectively, from 2002.1 to 2014.12 at the First Affiliated Hospital of Fujian Medical University. Results:43.8% were diagnosed occasionally during health examination, of the symptomatic cases: 50.0% were abdominal pain、25.0% were abdominal mass; the BMI was normal or hyper-normal in 92.3%. The detection of AFP、CEA、CA125、CA199 were all negative. 93.8% were single, 6.2% was multiple with one an the head and another an the body, the average was 5.16 in diameter, 94.1% were greater than 2.0 in diameter and 52.9% than 5.0; 41.2% were cystic, 23.5% had calcification; 47.1% located an the head and 35.3% at body and 17.6% at the tail. Ultrasound、CT and MRI could detect all tumours. 9 cases received ultrasound, 77.8% had shape margin, 88.9% presented hypo-echo. 15 cases received CT, 62.5% had shape margin, 93.8% presented hypo-density during pre-enhanced scanning; 86.7% presented hyper-enhanced during enhanced pattern, 86.7% presented mixed-enhanced; 40.0% presented compressed behavior. 4 cases received MRI, 75.0% presented hypo-intense on T1-weighted sequences, all presented hyper-intense on T2-weighted sequences; all presented hyper-intense during enhanced pattern. The combination of CT scanning and calcification、CT scanning and cystic、CT scanning and both calcification and cystic、hypo-density during pre-enhanced CT scanning and hyper-enhanced during CT enhanced pattern、hypo-echo during ultrasound and both hypo-density during pre-enhanced CT scanning to hyper-enhanced during CT enhanced pattern could reduce mis-diagnostic rate. 13 cases received surgery, 3 cases received non-surgery therapy; 15 cases had follow-up, the patients at an early TNM stage and received operation presented a good prognosis. Conclusions:Non functional pancreatic neuroendocrine tumours is asymptomatic, so it’s hard to diagnose at a early time, while it’s special at imaging; receiving surgery at a early time have a good prognosis.