Obstructive Sleep Apnea Hypopnea Syndrome Effects On Left Ventricular Mass And Function

Objective:Application of echocardiography to detemine left ventricular mass(LVM) in patients with Obstructive sleep apnea hypopnea syndrome(OSAHS) and the index of myocardial performance(IMP),assessment of OSAHS effects on left ventricular mass and function.Methods:One hundred and Sixteen subjects without complications referred for evaluation of OSAHS underwent overnight polysomnography and complete echocardiographic assessment.According to the apnea hypopnea index(AHI), subjects were divided into three groups: group 1, control subjects(AHI < 5, n = 32); group 2,patients with mild to moderate OSA(AHI: 5–30, n = 46); and group 3, severe OSA(AHI > 30, n = 38). Basic echocardiographic measurements, through the related formula,LVM, LVM index and left ventricular IMP were measured,carries on the statistical analysis.Results:There were no significant differences in age, sex, body mass index, heart rate,and systolic and diastolic blood pressure among the three groups. Left atrium, left ventricular end-diastolic and end-systolic diameters were not significantly different among the three groups. Interventricular septum, left ventricular posterior wall and LVM were significantly different among the three groups(P<0.05). LVM were significantly different between severe OSAHS patients(268.3±38.0)and controls(245.6±37.3,P=0.01),There was no significant difference between controls(245.6±37.3) and mild to moderate OSAHS(257.9±37.9,P=0.16) and between mild to moderate OSAHS(257.9±37.9) and severe OSAHS(268.3±38.0,P=0.21). LVM index were significantly higher in severe OSAHS patients(108.1±12.0)than in controls(98.9±11.4,P<0.01). There was no significant difference between controls(98.9±11.4)and mild to moderate OSAHS(103.7±11.9,P=0.07)and between mild to moderate OSAHS(103.7±11.9)and severe OSAHS(108.1±12.0,P=0.09). Left ventricular IMP was significantly higher in severe OSAHS patients(0.64±0.2)than in controls(0.51±0.2,P<0.01). There was no significant difference between controls(0.51±0.2)and mild to moderate OSAHS(0.58±0.2,P=0.13)and between mild to moderate OSAHS(0.58±0.2)and severe OSAHS(0.64±0.2,P=0.17).Conclusion:The present study demonstrates that patients with severe OSAHS have left ventricular hypertrophy(LVH) and global left ventricular dysfunction.