Studies On The Stereoselective Synthesis Of Homoiodo Allylsilane And Total Synthesis Of Artemisinin

This thesis aims at the studies on the new method for synthesis of highly substituted and functionalized stereoselective homoiodo allysilanes and total synthesis of natural anti-malarial compound Artemisinin, which consists of mainly the following two parts:In Chapter 1, a rational design and development of a general stereoselective method for the synthesis of highly substituted and functionalized allysilanes is described. By varying the substituents on the silicon atom, alkoxylmethylene substituted tertiary alcohol compound is expected to form an intermediate structure of a five-membered ring in the process of opening the ring, whereby in the cyclopropane ring-opening process to control the synthesis of polyfunctional allyl stereoselective group of silicon(Scheme 1).Scheme 1In Chapter 2, an overview of the background and circumstances of the Artemisinin synthesis route is presented firstly. The key intermediate route of artemisinin is designed based on our research group of allylsilane functional groups in the total synthesis(Scheme 2).Scheme 2...