Influences Of Atorvastatin Calcium In Different Doses On Vascular Endothelial Function In Patients With Coronary Atherosclerotic Heart Disease

To observe the influences of Atorvastatin Calcium in different doses on vasc ular endothelial function in patients with coronary atherosclerotic heart disease.Methods The patients(n=120) were divided, according to the level of low-den sity lipoprotein-cholesterol(LDL-C), into 4 groups:10 mg group(2.6 mmol/L≤LDL-C<3.64 mmol/L,n=30, treated with Atorvastatin Calcium, 10 mg/d); 20 mg group(3.64 mmol/L≤LDL-C<4.16 mmol/L,n=30, treated with Atorvastatin Calcium, 20 mg/d), 40 mg group(LDL-C≥4.16 mmol/L,n=30, treated with Atorvastatin Calciu m, 40 mg/d), and control group(LDL-C<2.6 mmol/L,n=30, not treated with Atorv astatin Calcium). The changes of flow-mediated dilatation(FMD) and nitroglycerinmediated dilatation(NMD) were detected by using color Doppler ultrasonic diagno stic apparatus.The levels of serum total cholesterol(TC), triglyceride(TG), LDL-C and high-density lipoprotein-cholesterol(HDL-C) were detected conventionally.Results Before treatment, the basis value of brachia diameter, FMD and NMD had no statistical difference between all Atorvastatin Calcium groups and control group(P>0.05). After treatment for 8 w, the basis value of brachia diameter and NMD had no statistical difference in all Atorvastatin Calcium groups(P>0.05) and the difference in NMD had no statistically significance between all Atorvastatin Calcium groups and control group(P>0.05). FMD increased significantly, and thedi fference was statistically significant compared with control group(P<0.05).Conclusion Atorvastatin Calcium can improve vascular endothelial function in patients with coronary atherosclerotic heart disease, and there is no dose-effect rela tionship in its mechanism of ameliorating level of blood fat.