The Role Of Diffusion Weighted Imaging To Assess Intracranial Lymphoma Treatment Response After Radiotherapy

Objective The objective of our study was to observe the changes of apparent diffusion coefficients(ADCs) in intracranial lymphoma before and after radiotherapy, and to investigate the value of ADCs in assessment Intracranial Lymphoma after radiotherapy.Materials and Methods Collection of 14 cases of pathologically confirmed intracranial lymphomas of magnetic resonance diffusion-weighted imaging data. All patients underwent DWI(b values = 0 and 1,000 s/mm2) before and 2 weeks after standard radiotherapy. The ADCs value were measured and compared in the enhancing tumor parenchyma, the contralateral normal area, edema area of tumor respectively and the contralateral edema area of tumor. Treatment response was determined according RECIST 1.1 after therapy and was classified as complete response(CR), partial response(PR), stable disease(SD), or progressive disease(PD). The difference ADC value of tumor parenchyma, the contralateral normal area, edema area,the contralateral edema area and the difference the long diameter were compared before and after radiotherapy with Paired- Sample T test; The of ADC value, the percentage changes of ADCs and the percentage changes of parenchyma max diameters were compared between PR and SD before and after radiotherapy respectively with Independent Sample T test; Pearson’s correlation test was calculated between the percentage changes of ADCs and the percentage changes of parenchyma max diameters.Results The ADCs of after radiotherapy for all intracranial lymphomas, PR and CR had a significantly higher than before therapy(P=0.000), the changes of parenchyma max diameters after radiotherapy for all intracranial lymphomas, PR and CR had a significantly smaller than before therapy(P=0.000). The ADCs of after radiotherapy between PR and SD had statistically significantly(P<0.05), PR was relatively high SD after radiotherapy. There were not correlations between the percentage changes of ADCs and the percentage changes of parenchyma max diameters, both PR and SD.Conclusion ADC values of intracranial lymphoma were significantly higher than the pre-treatment after radiation therapy, and earlier than the changes of parenchyma max diameters。The results suggest that ADCs have the potential capacity to assess and early monitor of Radiotherapy treatment response.