The Expression And Significance Of Smad2 And P38MAPK In Hepatic Tissues Next To Echinococcus Multilocularis

Objective:To observe the expression level of Smad2 and P38 MAPK protein in liver tissues of human with E.m,and to evaluate their interaction and the mechanism of signals in hepatic fibrosis.Method:20 patients who were diagnosed with AE through surgery were recruited and their hepatic tissues were divided into para-lesion and normal liver tissues.IHC was applied to detect the expression of Smad2 and P38 MAPK.Pathologic changes and the degree of hepatic fibrosis were evaluated using HE and Masson staining.Result:1,The scores of HF in para-lesions was higher than that in normal liver tissues; 2,The expression level of Smad2 and P38 MAPK in para-lesion were both higher than that in normal liver tissues; 3, The expression level of Smad2 and P38 MAPK in normal liver tissues, para-lesion or the whole hepatic tissues were all positively correlated with the degree of fibrosis;The expression level of Smad2 and P38 MAPK increased with the degree of fibrosis;4,The expression level of Smad2 was positively correlated with that of P38 MAPK in para-lesion.Conclusion:1,The degree of fibrosis in para-lesion with E.m is more serious than that in normal liver tissues;2,Smad2 and P38 MAPK are both involved in the process of liver fibrosis;3, P38 MAPK is involved in the regulation of Smad2 in para-lesion...