Influence Of OSAHS On Cognitive Function And Plasma ET-1 And Hcy Concentration In Patients With Hypertensive Cerebral Hemorrhage

Objectives To investigate the effect of obstructive sleep apnea syndrome patients on hypertensive intracerebral hemorrhage cognitive function, plasma endothelin-1 and plasma homocysteine.Methods 1 Selecting two groups of hypertensive intracerebral hemorrhage patients according with the diagnosis standard of OSAHS in the Affiliated Hospital of Hebei United University from 2012.12 to 2014.5, 77 cases for OSAHS complicated with hypertensive intracerebral hemorrhage patients(case group), 83 cases for hypertensive intracerebral hemorrhage patients(control group), with age, gender, BMI, blood pressure,bleeding site, amount of bleeding, chronic disease and education matched. 2 Using the mini mental state examination(MMSE) and loewenstein occupational therapy cognitive assessment(LOTCA) scale, to evaluating cognitive function of the two groups to understand the situation of cognitive dysfunction. 3 Plasma ET-1 and plasma Hcy levels of the two groups were detected using radiation immunization and cyclic enzymatic. 4 Monitored nocturnal sleep breathing of the two groups using polysomnography(PSG). 5 All data were established a database by excel, analyzed by statistical software SPSS17.0. Measurement data was adopted by t-test, count data was adopted by chi-square test. The specificity correlation analysis was adopted by Pearson correlation analysis.Results 1 Results of general data between the two groups: There was no significant difference between the two groups with regard to the scores with general data between the two groups(P>0.05). 2 The incidence of severe cognitive disorders accounted for 24.10%in the control group, while 62.34% in the case group(x2=23.903, P<0.05). 3 MMSE and LOTCA total scores of the case group were lower than the control group, the difference was statistically significant(P < 0.05). There was no significant difference in the two groups of patients with LOTCA score of directional force evaluation project(P>0.05). 4MMSE and LOTCA scores of patients with moderate or severe OSAHS complicated with hypertensive intracerebral hemorrhage were lower than mild ones. The difference was statistically significant(P < 0.05). 5 Plasma ET-1 and Hcy concentration in the case group were higher than those in the control group. The difference was statistically significant(P<0.05). 6 The plasma concentration levels of ET-1 and Hcy in patients with moderate or severe OSAHS complicated with hypertensive intracerebral hemorrhage were higher than that mild ones, the difference was statistically significant(P < 0.05). 7 The results of correlation analysis showed that the MMSE and LOTCA score were respectively negative correlated with Apnea Hypopnea Index(AHI), while positive correlated withLowest Oxygen Saturation(LSa O2)(P<0.01). The plasma concentration of ET-1 and Hcy levels were positive correlated with MMSE and LOTCA scores, while respectively negative correlated with Lowest Oxygen Saturation(LSa O2)(P<0.01).Conclusions 1 OSAHS can aggravate severity of cognitive dysfunction of patients with hypertensive intracerebral hemorrhage. 2 OSAHS increased plasma ET-1, Hcy levels in patients of hypertensive cerebral hemorrhage, it increases associated with cognitive disorder formation.