Research Of Biocompatibility Of Pure Magnesium Ultrasonic Micro-arc Oxidation-HF-silica Sol Compounded Treatment.

Objective : With the rapid development of science and technology,and the improvement of people’s life quality, medical biological material has been more and more scholars concern and research. Magnesium because of its good mechanical performance, biological degradable in the body and the biocompatibility make magnesium had a very good development prospect in the field of medical materials. But magnesium degrade too fast in the body, to control the degradation become a research hotspot. After micro-arc oxidation on the surface of a pure magnesium, then through two different method that silicon sol and HF- silicon sol composite processing, to control the degradation velocity of magnesium, but the cells biocompatibility needs further study.This paper mainly discusses the coatings by different treated influence on the activity,adhesion and proliferation of osteoblast,evaluating the pure magnesium surface of micro-arc oxidation after different composite coating cell compatibility.Methods: Experiment is divided into three groups, pure magnesium micro-arc oxidation group as the control group(group A), pure magnesium micro-arc oxidation- silica sol composite treatment group(group B), pure magnesium micro-arc oxidation- HF- silica sol composite treatment group(group C). Tied MC3T3- E1 osteoblast vaccination in three groups of material surface, respectively by scanning electron microscopy(sem), laser confocal, CCK 8, ALP growth, adhesion and proliferation of osteoblast and activity test.Results: Confocal scanning electron microscopy(sem) and laser display group B and C group on the surface of cell growth and adhesion were superior to group A, group C is better than that of group B. CCK 8 and ALP detection results show that the three groups of materials on the surface of cell proliferation, activity of group C > B > A group, three groups of comparative differences are statistically significant. Pure magnesium by micro-arc oxidation surface After silicon sol and HF- silica sol composite treatment on the surface of pure magnesium by micro-arc oxidation will promote the adhesion, proliferation and differentiation of osteoblast,it has good biocompatibility, and the HF- silica sol composite coating is superior to the silica sol.Conclusions: Three groups of materials have good biocompatibility, and pure magnesium micro-arc oxidation- HF- silicon sol the biocompatibility of the composite treated the best.