The Clinical Study On The Effect Of Combination Of TCM And Western Medicine Treatment Of Obese PCOS With IR

Objective:This study is through clinical research to investigate the effect of invigorating the kidney and regulating menstruation cycles combined with metformin in the treatment of obese Polycystic ovary syndrome with insulin resistance, comparing with the simple application of invigorating kidney and regulating menstruation and the simple application of Western medicine therapy (metformin and Diane-35) before and after the treatment, including clinical symptoms, menstruation, pregnancy rate, female hormones and insulin resistance different. This study aims to find the best solution of the obese PCOS with insulin resistant and expect to enhance the efficacy, reduce side effect, so that more patients can be benefited.Methods:According to the clinical diagnostic criteria, we selected 90 cases of obesity with insulin resistance in PCOS patients at the First People’s Hospital of Yangzhou City from September 2013 to August 2014. They were randomly divided into groups of western medicine group, traditional Chinese medicine group and traditional Chinese medicine combined with western medicine group (hereinafter referred to as the combination group),30 cases in each group. The patients in western medicine were treated with metformin and Diane-35, the patients in Chinese group were treated with Chinese drugs and the combination group were treated with Chinese drugs and metformin. All the patients in the three groups were treated in three months. According with the exclusion standard of cases and rejecting the cases do not meet, we at last get 23 patients in western medicine group,28 patients in Chinese medicine group and 25 patients in the combination group. The BMI, acne, hirsutism, menstruation, pregnancy rate of the PCOS patients were recorded and the levels in serum of LH, FSH, T, E2, FPG, FINS were assayed before and after the treatment. The evaluation and statistics were done using SPSS17.0 for Windows software and the calculating data were expressed as x±S. Data before and after the treatment were used T test; categorical data were used chi square test; comparison between groups were used analysis of variance. Result:Combined use of Chinese and Western medicine is superior to the simple application of traditional Chinese medicine or the simple application of western medicine in improving clinical symptoms, menstruation, the female hormone and insulin resistance.Conclusion:The combination of TCM and western medicine can effectively improve the clinical symptoms and signs of obese PCOS with IR, can significantly reduce the levels of LH, FSH, LH/FSH, T, BMI and IR in patients and elevated the levels of E2 and pregnancy rate, witch is superior to the simple application of traditional Chinese medicine or the simple application of western medicine. At the same time, it can be able to shorten the course of treatment with TCM and reduce the side effects of western medicine, witch provide more suitable way for the clinical treatment of obesity PCOS with insulin resistance.